M3441

Midkine, human

≥90% (SDS-PAGE)

• Synonym(s): Heparin-binding growth/differentiation factor
• CAS Number: 170138-17-7
• MDL number: MFCD00677322
• UNSPSC Code: 12352202
• NACRES: NA.32

Properties

• biological source: synthetic
• Quality Level: 200
• assay: ≥90% (SDS-PAGE)
• packaging: pkg of 50 μg
• color: white
• UniProt accession no.: P21741
• storage temp.: −20°C
• Gene Information: human ... MDK(4192)

Description

Biochem/physiol Actions

Midkine, a heparin-binding growth factor, contains 121 amino acid residues with 5 disulfide bonds. It promotes the growth, survival, and migration of various cells, and plays roles in neurogenesis and epithelial mesenchymal interactions during organogenesis. The C-terminal portion contains the heparin-binding domain and the antigenicity and neurite-promoting sequences. Both the C- and N-terminals are necessary for the molecule′s neurotrophic effects.

Promotes the growth, survival, and migration of various cells, and plays roles in neurogenesis and epithelial mesenchymal interactions during organogenesis. The C-terminal portion contains the heparin-binding domain and the antigenicity and neurite-promoting sequences. Both the C- and N-terminals are necessary for the molecule′s neurotrophic effects.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)