M3170
α,β-Methyleneguanosine 5′-diphosphate sodium salt
≥98%
Synonym(s):
GMPCP, GPCP
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About This Item
Empirical Formula (Hill Notation):
C11H17N5O10P2 · xNa+
CAS Number:
Molecular Weight:
441.23 (free acid basis)
UNSPSC Code:
41106305
Recommended Products
assay
≥98%
form
solid
storage temp.
−20°C
Application
α,β-Methyleneguanosine 5′-diphosphate (GPCP; GMPCP) is a GDP methylene analog used to study vinblastine-induced self-association of tubulin. GMPCP is used as an alternative to calcium to produce helical tubes that support bacterial division via assembly of cytokinetic ring structures, Z-rings. GMPCP may be used in comparison with the more slowly hydrolyzed analog guanylyl-(α,β)-methylene-diphosphonate (GMPCPP).
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Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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J Löwe et al.
Biological chemistry, 381(9-10), 993-999 (2000-11-15)
Bacterial cell division depends on the formation of a cytokinetic ring structure, the Z-ring. The bacterial tubulin homologue FtsZ is required for Z-ring formation. FtsZ assembles into various polymeric forms in vitro, indicating a structural role in the septum of
A A Hyman et al.
The Journal of cell biology, 128(1-2), 117-125 (1995-01-01)
We have used cryoelectron microscopy to try to understand the structural basis for the role of GTP hydrolysis in destabilizing the microtubule lattice. We have measured a structural difference introduced into microtubules by replacing GTP with guanylyl-(alpha,beta)-methylene-diphosphonate (GMPCPP). In a
B Vulevic et al.
Biochemistry, 36(42), 12828-12835 (1997-10-23)
It is now well established that guanine nucleotides are allosteric effectors of the vinca alkaloid-induced self-association of tubulin. GDP enhances self-association for vinblastine-, vincristine- and vinorelbine-induced spiral assembly relative to GTP by 0.90 +/- 0.17 kcal/mol [Lobert et al. (1996)
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