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M2295

Sigma-Aldrich

Myelin Basic Protein from guinea pig brain

≥80% (SDS-PAGE), lyophilized powder, from guinea pig brain

Synonym(s):

MBP

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1 MG
$345.20
5 MG
$1,230.00

About This Item

MDL number:
MFCD00131640
UNSPSC Code:
12352202
NACRES:
NA.32

$345.20

List Price$374.00Save 8%
Web-Only Promotion

Available to ship onApril 29, 2025Details

Request a Bulk Order

biological source

guinea pig brain

Quality Level

200

assay

≥80% (SDS-PAGE)

form

lyophilized powder

technique(s)

cell based assay: suitable

UniProt accession no.

P25188

application(s)

cell analysis

storage temp.

−20°C

Gene Information

guinea pig ... MBP(100731253)

General description

Myelin Basic Protein (MBP) expressed in guinea pig brain contains 167 amino acids and has a molecular weight of 18,256Da.[1]
Research area: Cell SignallingMyelin basic protein (MBP) is an important constituent of the myelin sheath of CNS (central nervous system).[2] It is an auto-immunogen.[3]

application

Myelin Basic Protein fromguinea pig brain has been used as a kinase substrate: to analyse in vitrokinase activity[4], in protein phosphorylation analysis[5], in ATG1 kinaseassay[6]

Biochem/physiol Actions

Major structural protein of CNS myelin. Used to induce experimental allergic encephalomyelitis.
Mutation of the myelin basic protein gene induces dysmyelination; used to induce experimental allergic encephalomyelitis.
Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP function as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis.[7] MBP functions as an in vitro substrate for mitogen-activated protein kinase (MAP) kinase and aids in the purification and functional studies of enzyme.[8]

Quality

May contain traces of urea-glycine buffer salts.

Principle

Used as a kinase substrate.

related product

Product No.
Description
Pricing

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000276174
0000276171
0000259822
SLCL1846
SLCH5231

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Glucagon-Like Peptide-1 Analog, Liraglutide, Delays Onset of Experimental Autoimmune Encephalitis in Lewis Rats
Della VB, et al.
Frontiers in Pharmacology, 7, 787-802 (2016)
J A Last et al.
Toxicology, 39(3), 247-257 (1986-06-01)
A synergistic interaction, as defined by biochemical and morphological criteria, between ozone (or NO2) and respirable aerosols of ammonium sulfate or sulfuric acid has been described previously. Experiments in the present paper show that it is the acidity, not the
Metallic gold slows disease progression, reduces cell death and induces astrogliosis while simultaneously increasing stem cell responses in an EAE rat model of multiple sclerosis
Pedersen DS, et al.
Histochemistry and Cell Biology, 138(5), 787-802 (2012)
Sequence of guinea pig myelin basic protein.
Deibler GE
Journal of Neurochemistry, 43(1), 100-105 (1984)
Karine Thibault et al.
European journal of pain (London, England), 15(3), 231-231 (2010-09-11)
Multiple sclerosis is a chronic inflammatory demyelinating disease, associated, in 50-80% of patients, with persistent pain. While the type of pain that affects these patients is being more documented, the mechanisms underlying this pathology are still poorly understood and animal
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