Skip to Content
MilliporeSigma
Get up to 22% off for Pi Day through March 27.Save Now

M137

Methysergide maleate salt

solid

Slide 1 of 1
Sign In to View Organizational & Contract Pricing.

Select a Size

2 MG

$167.00

10 MG

$357.00

$167.00

Available to ship TODAYDetails

​
Request a Bulk Order
​
Ships Every 4 weeks

About This Item

Empirical Formula (Hill Notation):
C21H27N3O2 · C4H4O4
CAS Number:
129-49-7
Molecular Weight:
469.53
NACRES:
NA.77
PubChem Substance ID:
24278129
UNSPSC Code:
12352200
EC Number:
204-950-9
MDL number:
MFCD00083185
Form:
solid
Quality level:
100

Key Documents

View All Documentation

Skip To

Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

InChI key

LWYXFDXUMVEZKS-ZVFOLQIPSA-N

InChI

1S/C21H27N3O2.C4H4O4/c1-4-15(12-25)22-21(26)14-8-17-16-6-5-7-18-20(16)13(10-23(18)2)9-19(17)24(3)11-14;5-3(6)1-2-4(7)8/h5-8,10,14-15,19,25H,4,9,11-12H2,1-3H3,(H,22,26);1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15+,19-;/m1./s1

SMILES string

OC(=O)\C=C/C(O)=O.[H][C@@]12Cc3cn(C)c4cccc(C1=C[C@H](CN2C)C(=O)N[C@@H](CC)CO)c34

form

solid

color

white to off-white

solubility

DMSO: >10 mg/mL, H2O: 2 mg/mL

originator

Novartis

Quality Level

100

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR7(3363)

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
U115T123C231
Methysergide maleate salt solid

Sigma-Aldrich

M137

Methysergide maleate salt

U-101958 maleate salt solid

Sigma-Aldrich

U115

U-101958 maleate salt

Thioperamide maleate salt solid

Sigma-Aldrich

T123

Thioperamide maleate salt

CGP-20712A methanesulfonate salt solid, ≥98% (HPLC)

Sigma-Aldrich

C231

CGP-20712A methanesulfonate salt

form

solid

form

solid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

solubility

DMSO: >10 mg/mL, H2O: 2 mg/mL

solubility

DMSO: 11 mg/mL, ethanol: 2.7 mg/mL, H2O: 3 mg/mL

solubility

H2O: >10 mg/mL, DMSO: 12 mg/mL, ethanol: 3 mg/mL

solubility

H2O: >10 mg/mL, DMSO: 100 mg/mL

color

white to off-white

color

off-white

color

white

color

white to off-white

originator

Novartis

originator

-

originator

-

originator

-

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR7(3363)

Gene Information

human ... DRD4(1815)

Gene Information

human ... HRH3(11255)

Gene Information

human ... ADRB1(153)

Application

Methysergide maleate salt has been used as a serotonin (5HT) receptor antagonist to evaluate the potential systemic effects of methysergide (METH) and 5-HT infusions on production and milk composition in multiparous Holstein cows.[1] It may also be used as a serotonin receptor blocker to identify the serotonergic receptor type involved in the direct excitation of mitral cells in the main olfactory bulb.[2]

Biochem/physiol Actions

Methysergide maleate, also known as sansert,[3] is a semisynthetic ergot alkaloid ergometrine derivative.[4] Methysergide is a serotonin 1(5-HT1) receptor agonist and a nonselective 5-HT2 and 5-HT7 serotonin receptor antagonist.[1][2] Methysergide maleate is used as a pharmacological agent to treat migraines and other vascular headaches. But, prolonged and uncontrolled use of this drug may cause Leriche′s syndrome, angina pectoris, acute ischemia of the limbs. In addition, gastrointestinal side effects, such as abdominal cramps, nausea, and diarrhea have also been observed in few patients.[5]

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCN7273
BCCJ3384
BCCB1072
BCBZ1920
BCBT4806

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Acute ischemia of a limb complicating methysergide maleate therapy.
A L URELES et al.
JAMA, 183, 1041-1042 (1963-03-23)
J A Terrón
British journal of pharmacology, 121(3), 563-571 (1997-06-01)
1. The receptor mediating the long-lasting hypotensive effect of intravenous (i.v.) 5-hydroxytryptamine (5-HT) in the rat was originally classified as 5-HT1-like. Since some pharmacological properties of this receptor are closely similar to those for the cloned 5-ht7 receptor, the present
Seth D Depuy et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(6), 1981-1990 (2011-02-11)
We used optogenetics to determine the global respiratory effects produced by selectively stimulating raphe obscurus (RO) serotonergic neurons in anesthetized mice and to test whether these neurons detect changes in the partial pressure of CO(2), and hence function as central
N H Prins et al.
British journal of pharmacology, 127(6), 1431-1437 (1999-08-24)
This study aimed to characterize for the first time in vitro 5-HT4 receptors in the canine gastrointestinal tract. For this purpose, we used circular muscle strips of the canine isolated rectum. In the presence of methysergide (60 microM), 5-HT induced
E J Mylecharane
Clinical and experimental pharmacology & physiology, 16(6), 517-522 (1989-06-01)
1. The current classification of receptors for 5-hydroxytryptamine (5-HT) is based on functional studies, and encompasses three main receptor types. 2. 5-HT1-like receptors mediate inhibition of release of various neurotransmitters from central and peripheral sites, smooth muscle contraction and relaxation
View All Related Papers

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service