M1066

Mass Spectrometry in Drug Discovery

• ISBN-10: 0-8247-0607-2
• ISBN-13: 978-0-8247-0607-4
• UNSPSC Code: 55101509

Properties

• publication info: D.T. Rossi and M.W. Sinz, ed., Marcel Dekker, Inc., 2002, 432 pp., hard cover
• manufacturer/tradename: Marcel Dekker

Description

General description

This reference summarizes the theory, instrumentation, and application of mass spectrometry and atmospheric pressure ionization to screen, evaluate, and improve the performance and quality of drug candidates. It covers: recent advances in combinatorial chemistry, molecular biology, bioanalysis automation, and computing; cassette dosing; the utilization of liquid chromatography/mass spectrometry (LC/MS) in chemical library characterization, combinatorial chemistry, drug transport, and in vivo microdialysis; reliable methods of sample preparation and handling; novel strategies to determine and characterize metabolite structures; the impact of absorption, distribution, metabolism, and elimination properties on drug discovery.

Table of Contents

INTRODUCTION
The Demand for Drug Discovery Today
The Impact of Atmospheric Pressure Ionization
INSTRUMENTATION
A Mass Spectrometry Primer
EXPERIMENTAL STRATEGIES
Ion Chemistry and Fragmentation
The LC/MS Experiment
Sample Preparation and Handling for LC/MS in Drug Discovery
APPLICATIONS
Mass Spectrometry in Combinatorial Chemistry
Drug Hydrophobicity and Transport
The Mass Spectrometer in Drug Metabolism
Mass Spectrometry-Assisted Applications of Stable-Labeled Compounds in Pharmacokinetic and Drug Metabolism
Studies
Cassette Dosing in Drug Discovery
Applications of Microdialysis/Mass Spectrometry to Drug Discovery
Future Directions for Mass Spectrometry in Drug Discovery
Index