M0807

Anti-Matrix Metalloproteinase-12, C-Terminal antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

• Synonym(s): Anti-MMP-12
• MDL number: MFCD03097003
• UNSPSC Code: 12352203

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous glycerol solution
• species reactivity: human
• concentration: ~1 mg/mL
• technique(s): immunohistochemistry (frozen sections): suitable; immunoprecipitation (IP): suitable; indirect ELISA: suitable; western blot: 1:1,000
• UniProt accession no.: P39900
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... MMP12(4321)

Description

Specificity

Reacts with reduced MMP-12. The C-terminal recognizes most active forms of MMP-12. The hemopexin domain is cleaved in the final form of MMP-12 and the antibody does not detect this final form. The zymogen is approximately 54 kDa and is quickly activated to the 45 kDa form which breaks down to a cascade of active forms, ending with a 22 kDa form.

Immunogen

synthetic peptide corresponding to the C-terminal of human matrix metalloproteinase-12 (macrophage elastase).

Physical form

Solution in phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.