shipped in
dry ice
storage temp.
−20°C
General description
A set of 52 compounds are arranged in 96-well format, one compound per well (250 μl at 10 mM in DMSO)
Application
Cardiotoxicity Ligand Set has been used in the cumulative drug dosage studies on engineered human induced pluripotent stem cell-derived cardiomyocyte (hiPS-CM) tissues.[1]
Biochem/physiol Actions
Cardiotoxicity is an important cause for concern in drug development and appears to cut across therapeutic indications and drug classes. Several drugs have been removed from the market recently because of prolonging the QT interval or causing Torsades de Pointes (TdP).
The Cardiotoxicity Ligand Set features a wide variety of drugs including anti-arrhythmics, antihistamines, antibiotics, anticonvulsants, antidepressants and antipsychotics that are known to have cardiotoxic side-effects.
The Cardiotoxicity Ligand Set features a wide variety of drugs including anti-arrhythmics, antihistamines, antibiotics, anticonvulsants, antidepressants and antipsychotics that are known to have cardiotoxic side-effects.
Features and Benefits
SDFile provided to construct a database containing:
- Structure
- Primary Name
- Secondary Name
- Pharmacological Activity
- Product Number
- Rack Position
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 1 - Carc. 1A - Lact. - Repr. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Qi Tang et al.
Antiviral research, 173, 104650-104650 (2019-11-18)
IRES-driven translation plays an essential role in picornavirus infection. However, there are seldom reports of compounds targeting this pathway with effective protection in animal models. Here, we identified emetine, an antiprotozoal drug, which inhibits EV-A71 with an EC50 value of
Drug-induced prolongation of the QT interval.
Dan M Roden
The New England journal of medicine, 350(10), 1013-1022 (2004-03-05)
L Testai et al.
Current medicinal chemistry, 11(20), 2691-2706 (2004-11-17)
Many non-cardiovascular drugs of common clinical use cause, as an unwanted accessory property, the prolongation of the cardiac repolarisation process, due to the block of the HERG (Human Ether-a-go-go Related Gene) potassium channel, responsible for the repolarising I(Kr) current. This
Alexander N Katchman et al.
The Journal of pharmacology and experimental therapeutics, 316(3), 1098-1106 (2005-11-10)
The purpose of the present study was to comparatively evaluate human HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs. Various concentrations of 14 different drugs were initially evaluated in terms of their relative potency to
Cardiac microphysiological devices with flexible thin-film sensors for higher-throughput drug screening
Lind JU, et al.
Lab on a chip, 17(21), 3692-3703 (2017)
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