L9544
Anti-Livin (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-BIRC7, Anti-Baculoviral IAP repeat-containing 7, Anti-KIAP, Anti-MLIAP, Anti-RNF50
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~39 kDa
species reactivity
human
packaging
antibody small pack of 25 μL
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 5-10 μg using lysate of HEK-293T cells expressing human Livin
western blot: 2.5-5.0 μg/mL using whole extract of HEK-293T cells expressing human Livin
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... BIRC7(79444)
General description
Livin or baculoviral IAP repeat-containing 7 (BIRC7) belongs to the family of the inhibitor of apoptosis proteins (IAP). It contains a single copy of a baculovirus IAP repeat (BIR) as well as a really interesting new gene (RING)-type zinc finger domain. Structurally, livin comprises a three-stranded anti-parallel β-sheet and four α-helices and takes a globular architecture. BIRC7 gene is mapped to human chromosome 20q13.33 and is expressed in α and β isoforms.
Specificity
Anti-Livin (C-terminal) recognizes human Livin/BIRC7.
Application
Anti-Livin (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.
Biochem/physiol Actions
Livin or baculoviral IAP repeat-containing 7 (BIRC7) inhibitory functionality is mediated by the baculovirus inhibitor of apoptosis proteins (IAP)repeat (BIR) domain. This domain is also essential for interaction with caspases. The really interesting new gene (RING) finger domain elicits E3-ubiquitin ligase activity in the absence of BIR domain. The two isoforms of livin have different antiapoptotic properties, with isoform protecting cells from apoptosis induced by staurosporine and isoform α protecting cells from apoptosis induced by etoposide. An elevated expression of Livin is detected in prostate, breast, colon, head and neck squamous cell carcinoma. Inhibition of livin in nasopharyngeal carcinoma (NPC) leads to improved irradiation sensitivity in NPC cells.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2–8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Dongyuan Wu et al.
International heart journal, 58(5), 769-777 (2017-10-03)
In this study, we investigated the protection effect of Vitamin E (Vit E) on formaldehyde (FA) exposure during pregnancy induced apoptosis of cardiomyocytes, and used an HL-1 cell line to confirmed the findings in vivo.Pregnant mice received different doses of
Fei Ma et al.
PloS one, 15(3), e0229272-e0229272 (2020-03-03)
Radiotherapy is one of the major remedies for the treatment of cancer, including nasopharyngeal carcinoma (NPC). Radioresistance occurs very often in target cells that is a large drawback in cancer treated with radiotherapy. Livin involves the over-growth of cancer cells.
Boaz Nachmias et al.
Cancer research, 63(19), 6340-6349 (2003-10-16)
Inhibitor of apoptosis protein (IAP) is a family of intracellular proteins that plays an essential role in the regulation of apoptosis. Recently, we and others discovered a new member of this family, termed Livin. Many studies have focused on the
Ling Wang et al.
Molecular cancer therapeutics, 7(12), 3661-3669 (2008-12-17)
Livin is a member of the inhibitors of apoptosis protein gene family, which is highly expressed in a variety of human neoplasms. Several studies have shown that down-regulation of Livin expression increases the apoptotic rate, reduces tumor growth potential, and
Irena Crnković-Mertens et al.
Journal of molecular medicine (Berlin, Germany), 84(3), 232-240 (2006-01-27)
Livin (alternatively called ML-IAP or KIAP) is a cancer-associated member of the antiapoptotic inhibitor of apoptosis protein family. Two splicing variants of Livin, designated Livin alpha and Livin beta, have been identified. The significance of these isoforms for Livin-mediated apoptosis
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