Skip to Content
MilliporeSigma
All Photos(3)

Key Documents

L5768

Sigma-Aldrich

Lanosterol

≥93%, powder

Synonym(s):

3β-Hydroxy-8,24-lanostadiene, 8,24-Lanostadien-3β-ol

Sign Into View Organizational & Contract Pricing

Select a Size

1 MG
$130.00
5 MG
$458.00

$130.00


In StockDetails


Request a Bulk Order

Select a Size

Change View
1 MG
$130.00
5 MG
$458.00

About This Item

Empirical Formula (Hill Notation):
C30H50O
CAS Number:
Molecular Weight:
426.72
EC Number:
MDL number:
UNSPSC Code:
12352211
PubChem Substance ID:
NACRES:
NA.77

$130.00


In StockDetails


Request a Bulk Order

Quality Level

assay

≥93%

form

powder

color

white to off-white

storage temp.

−20°C

SMILES string

[H][C@@]1(CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](O)C(C)(C)[C@]4([H])CC3)[C@H](C)CC\C=C(/C)C

InChI

1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1

InChI key

CAHGCLMLTWQZNJ-BQNIITSRSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Lanosterol, an amphipathic molecule, that is produced by lanosterol synthase (LSS). It is enriched in the lens.[1]

Application

Lanosterol has been used:
  • as a standard in HPLC for the quantification in testis samples[2]
  • in S-adenosyl-L-methionine:Δ24-sterol-C-methyltransferase (SMT) assay[3]
  • to treat wild-type cells growing in rich medium to know its effects on Sre1 protein[4]

Biochem/physiol Actions

Cholesterol precursor sterol.
Lanosterol serves as an endogenous selective modulator of macrophage immunity.[5]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Identification and Characterization of an S-Adenosyl-L-methionine:-Sterol-C-methyltransferase cDNA from Soybean
Shi J, et al.
The Journal of Biological Chemistry, 271(16), 9384-9389 (1996)
Marja-Riitta Taskinen et al.
Journal of clinical lipidology, 14(1), 77-87 (2020-01-10)
Monoclonal antibodies to proprotein convertase subtilisin/kexin type 9 (PCSK9) significantly lower the levels of low-density lipoprotein and very-low-density lipoproteins (VLDL), but their effect on postprandial lipoprotein metabolism in dyslipidemic subjects is unclear. This study aimed to investigate the effects of
Lanosterol reverses protein aggregation in cataracts
Zhao L, et al.
Nature, 523(7562), 607-607 (2015)
Lorena Fernández-Cabezón et al.
Frontiers in microbiology, 9, 958-958 (2018-06-06)
Nowadays steroid manufacturing occupies a prominent place in the pharmaceutical industry with an annual global market over $10 billion. The synthesis of steroidal active pharmaceutical ingredients (APIs) such as sex hormones (estrogens, androgens, and progestogens) and corticosteroids is currently performed
Evgeniy O Yablokov et al.
Biochimie, 162, 156-166 (2019-04-30)
The aim of the present work was to establish the thermodynamic and functional differences in the protein-protein interactions between the components of the P450-dependent mitochondrial (mit) and microsomal (mic) monooxygenase systems using 12 different isoforms of cytochromes P450 and two

Articles

Cholesterol biosynthesis starts in the hepatic endoplasmic reticulum with acetyl-CoA, yielding 3-hydroxy-3-methylglutaryl-CoA via HMG-CoA synthase.

Discover Bioactive Small Molecules for Lipid Signaling Research

Questions

1–2 of 2 Questions  
  1. How to prepare this product for cell experiments?

    1 answer
    1. The product has not been tested for use in cell culture, and its solubility has been tested at 100 mg/mL in chloroform.

      Helpful?

  2. How to prepare this product for cell experiments?

    1 answer
    1. This product is not tested for use in cell culture. The solubility is tested at 100 mg/mL in Chloroform. See the link below to a publication that may be helpful.
      https://www.sciencedirect.com/science/article/pii/S0167488919302253

      Helpful?

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service