L4912

Leptin Receptor/Fc Chimera from mouse

≥97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

• Synonym(s): B219
• MDL number: MFCD02099416
• UNSPSC Code: 51111800

Properties

• recombinant: expressed in NSO cells
• assay: ≥97% (SDS-PAGE)
• form: lyophilized powder
• technique(s): cell culture | mammalian: suitable
• impurities: endotoxin, tested
• UniProt accession no.: P48356
• storage temp.: −20°C
• Gene Information: mouse ... Lepr(16847)

Description

Biochem/physiol Actions

Leptin receptor (OB-R) is a single membrane-spanning receptor most related to the gp-130 signal-transducing component of the IL-6 receptor, the G-CSF receptor and the LIF receptor. OB-R, also known as B219, is expressed in the yolk sac, early fetal liver, enriched hematopoitic stem cells and in a variety of lymphohematopoietic cell lines. OB-R is also expressed at high levels in adult reproductive organs. OB-RL action in hepatic cells may be equivalent to that of IL-6 receptor. Leptin does not play a specific role in muting insulin action on hepatoma cells and may not contribute to the diabetic symptoms associated with obesity.

Leptin receptor is important for regulating appetite and energy expenditure.[1] The neuroendocrine hormone, leptin, works through leptin receptor. In humans and mice, problems in expression of leptin or leptin receptor are associated with obesity.[2]

Physical form

Lyophilized from 20 mM Tris containing 5 mg of bovine serum albumin per 100 μg leptin receptor.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)