L4787

Leptin Receptor/Fc Chimera human

≥97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

• Synonym(s): B219
• MDL number: MFCD02099416
• UNSPSC Code: 51111800

Properties

• recombinant: expressed in NSO cells
• assay: ≥97% (SDS-PAGE)
• form: lyophilized powder
• technique(s): cell culture | mammalian: suitable
• UniProt accession no.: P48357
• storage temp.: −20°C
• Gene Information: human ... LEPR(3953)

Description

General description

The gene LEPR (leptin receptor) is mapped to human chromosome 1p31. The neuroendocrine hormone, leptin, works through leptin receptor.

Biochem/physiol Actions

Leptin receptor (LEPR) is linked with risk of coronary artery disease. Mutation in LEPR is associated with low BMI (body mass index), increased leptin levels and some cancers. In humans and mice, problems in expression of leptin or leptin receptor are associated with obesity.

Leptin receptor (OB-R) is a single membrane-spanning receptor most related to the gp-130 signal-transducing component of the IL-6 receptor, the G-CSF receptor and the LIF receptor. OB-R, also known as B219, is expressed in the yolk sac, early fetal liver, enriched hematopoitic stem cells and in a variety of lymphohematopoietic cell lines. OB-R is also expressed at high levels in adult reproductive organs. OB-RL action in hepatic cells may be equivalent to that of IL-6 receptor. Leptin does not play a specific role in muting insulin action on hepatoma cells and may not contribute to the diabetic symptoms associated with obesity.

Physical form

Lyophilized from 20 mM Tris containing 5 mg of bovine serum albumin.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)