LY-367385 hydrochloride has been used as a non-N-methyl-D-aspartate (NMDA) glutamate receptor blocker in neuronal stimulation experiment.[1]
Biochem/physiol Actions
LY-367385 hydrochloride has an ability to inhibit induction of long-term potentiation (LTP).[2]
LY-367385 is a selective metabotropic glutamate 1a receptor (mGlu1a) antagonist.
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Tonically active cholinergic interneurons (TANs) from the nucleus accumbens (NAc) are centrally involved in reward behavior. TANs express a vesicular glutamate transporter referred to as VGLUT3 and thus use both acetylcholine and glutamate as neurotransmitters. The respective roles of each
Synaptic activity induces input-specific rearrangements in a targeted synaptic protein interaction network
Abnormally increased neuronal activity in the lateral habenula (LHb) is closely associated with depressive-like behavior. Despite the emphasis on the pathological importance of NMDA receptor (NMDAR)-dependent long-term depression (LTD) and the involvement of calcium permeable AMPA receptor (CP-AMPAR) as major
Dopamine is involved in physiological processes like learning and memory, motor control and reward, and pathological conditions such as Parkinson's disease and addiction. In contrast to the extensive studies on neurons, astrocyte involvement in dopaminergic signaling remains largely unknown. Using
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