L3169

LP 12 hydrochloride hydrate

≥98% (HPLC), solid

• Synonym(s): 4-(2-Diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1- piperazinehexanamide hydrochloride
• Empirical Formula (Hill Notation): C₃₂H₃₉N₃O·HCl · xH₂O
• Molecular Weight: 518.13 (anhydrous basis)
• MDL number: MFCD11114387
• UNSPSC Code: 12352200
• PubChem Substance ID: 329817403
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: solid
• color: off-white
• solubility: DMSO: >5 mg/mL; H₂O: 6 mg/mL
• storage temp.: −20°C
• SMILES string: O.Cl.O=C(CCCCCN1CCN(CC1)c2ccccc2-c3ccccc3)NC4CCCc5ccccc45
• InChI: 1S/C32H39N3O.ClH.H2O/c36-32(33-30-18-11-15-26-14-6-7-16-28(26)30)20-5-2-10-21-34-22-24-35(25-23-34)31-19-9-8-17-29(31)27-12-3-1-4-13-27;;/h1,3-4,6-9,12-14,16-17,19,30H,2,5,10-11,15,18,20-25H2,(H,33,36);1H;1H2
• InChI key: VOKWUIAIZYWMDR-UHFFFAOYSA-N

Description

Biochem/physiol Actions

LP 12 dihydrochloride is a 5-HT7 receptor agonist displaying selectivity over D2, 5-HT1A and 5-HT2A receptors (Ki values are 0.13, 224, 60.9 and 1464 nM, respectively. It also displays selectivity over D2, 1723; over 5-HT1A, 468; over 5-HT2A, 11261; and high potency. Sigma has added LP 44 (L9793) which shows significantly lower D2 selectivity (7.3 nM/0.22 nM for 33-fold), lower selectivity over 5-HT1A, 240; and over 5-HT2A, 1482. LP 12 and LP 44 seem to share a common intermediate.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)