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L3044

Sigma-Aldrich

Monoclonal Anti-LRRK2 antibody produced in mouse

~1.0 mg/mL, clone PROK57, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-AURA17, Anti-Dardarin, Anti-Leucine-rich repeat protein kinase 2, Anti-PARK8, Anti-RIPK7, Anti-ROCO2

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About This Item

UNSPSC Code:
12352203

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

PROK57, monoclonal

form

buffered aqueous solution

mol wt

antigen ~250 kDa

species reactivity

mouse, human

concentration

~1.0 mg/mL

technique(s)

immunocytochemistry: suitable
indirect ELISA: suitable
western blot: 1-2 μg/mL using mouse brain crude extract

isotype

IgM

UniProt accession no.

Q5S007

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... LRRK2(120892)
mouse ... Lrrk2(66725)

General description

LRRK2 is a μLtimeric kinase that also functions as a GTPase. LRRK2 activates a CaMKK-β/AMPK signaling pathway and subsequently mediates autophagy. Genetic alterations in LRRK2 cause late-onset Parkinson′s disease . Monoclonal Anti-LRRK2 antibody is specific for human and mouse LRRK2.

Application

Monoclonal Anti-LRRK2 antibody is suitable for use in western blot (1-2 μg/mL using mouse brain crude extract), immunoblot (approx. 250 kDa), indirect ELISA and immunocytochemistry.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
078K4797

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Vasanti S Anand et al.
The FEBS journal, 276(22), 6428-6435 (2009-10-07)
Leucine-rich repeat kinase 2 (LRRK2) is a large, complex, multidomain protein containing kinase and GTPase enzymatic activities and multiple protein-protein interaction domains. Mutations linked to autosomal dominant forms of Parkinson's disease result in amino acid changes throughout the protein and
Patricia Gómez-Suaga et al.
Human molecular genetics, 21(3), 511-525 (2011-10-21)
Mutations in the leucine-rich repeat kinase-2 (LRRK2) gene cause late-onset Parkinson's disease, but its physiological function has remained largely unknown. Here we report that LRRK2 activates a calcium-dependent protein kinase kinase-β (CaMKK-β)/adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathway which is

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