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L2275

Sigma-Aldrich

Myosin Light Chain Kinase Fragment 11-19 amide

≥97% (HPLC)

Synonym(s):

Lys-Lys-Arg-Ala-Ala-Arg-Ala-Thr-Ser amide

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About This Item

Empirical Formula (Hill Notation):
C40H78N18O11
CAS Number:
119386-39-9
Molecular Weight:
987.16
MDL number:
MFCD00076722
UNSPSC Code:
12352202
PubChem Substance ID:
24896310
NACRES:
NA.26

assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

CC(O)C(NC(=O)C(C)NC(=O)C(CCCNC(N)=N)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCCN)NC(=O)C(N)CCCCN)C(=O)NC(CO)C(N)=O

InChI

1S/C40H78N18O11/c1-20(52-36(67)27(14-10-18-50-40(47)48)56-37(68)25(12-6-8-16-42)55-34(65)24(43)11-5-7-15-41)31(62)51-21(2)32(63)54-26(13-9-17-49-39(45)46)35(66)53-22(3)33(64)58-29(23(4)60)38(69)57-28(19-59)30(44)61/h20-29,59-60H,5-19,41-43H2,1-4H3,(H2,44,61)(H,51,62)(H,52,67)(H,53,66)(H,54,63)(H,55,65)(H,56,68)(H,57,69)(H,58,64)(H4,45,46,49)(H4,47,48,50)

InChI key

FDCBNCDCLDMQDU-UHFFFAOYSA-N

Amino Acid Sequence

Lys-Lys-Arg-Ala-Ala-Arg-Ala-Thr-Ser-NH2

Biochem/physiol Actions

Myosin Light Chain Kinase (MLCK) Fragment 11-19 amide (Lys-Lys-Arg-Ala-Ala-Arg-Ala-Thr-Ser-NH2) is used as an inhibitor of Myosin Light Chain Kinase phosphorylation.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
069K1362
127K1565
057K1160
086K2164
073K1204

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R B Pearson et al.
The Journal of biological chemistry, 261(1), 25-27 (1986-01-05)
The COOH-terminal residue in peptide analogs of the phosphorylation site sequence in smooth muscle myosin light chains, Lys11-Lys12-Arg13-Ala-Ala-Arg16-Ala-Thr-Ser19 -(P)Asn20-Val21-Phe22-Ala23, were shown to have a strong influence on the kinetics of peptide phosphorylation. The peptides 11-19, 11-20, 11-21, 11-22, and 11-23
P J Kennelly et al.
The Journal of biological chemistry, 262(25), 11958-11963 (1987-09-05)
A synthetic peptide modeled after the calmodulin (CaM)-binding domain of rabbit skeletal muscle myosin light chain kinase, Lys-Arg-Arg-Trp-Lys5-Lys-Asn-Phe-Ile-Ala10-Val-Ser-Ala-Ala-+ ++Asn15-Arg-Phe-Glycyl amide (M5), inhibited the CaM-independent chymotryptic fragment of the enzyme, C35 (Edelman, A. M., Takio, K., Blumenthal, D. K., Hansen, R.
J T Hunt et al.
The Biochemical journal, 257(1), 73-78 (1989-01-01)
Although the amino acid residues that are important for peptide substrates of myosin light-chain kinase have been reported, those that are important for peptide inhibitors of this enzyme have not previously been investigated. Synthetic peptides based on the sequence Lys11-Lys12-Arg13-Ala-Ala-Arg16-Ala-Thr-Ser19

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