K4760
Anti-Keratinocyte Growth Factor antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-FGF-7, Anti-KGF
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About This Item
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biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 15 μg/mL
indirect ELISA: 0.5-1 μg/mL
neutralization: suitable
western blot: 0.1-0.2 μg/mL
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... FGF7(2252)
General description
Keratinocyte growth factor (KGF, FGF-7) is a member of the fibroblast growth factor (FGF) family and is produced by cells of mesenchymal origin. The receptor for KGF is primarily expressed on the surface of epithelial cells and mediates mesenchymal-epithelial communication. There are multiple functions for KGF including proliferation, migration, DNA repair, differentiation, survival and production of enzymes to nullify the effects of reactive oxygen species. The expression of KGF is reportedly induced by cytokines such as IL-1 and transforming growth factor-α. Some of the pathways that are influenced by KGF are Akt, RSK1 and PAK4. Recent studies implicate KGF in epithelial tumorigenesis under specific situations
Anti-Keratinocyte Growth Factor recognizes human FGF-7. This antibody shows less than 20% cross-reactivity with human FGF-9 and less than 10% cross-reactivity with human FGF-4.
Anti-Keratinocyte Growth Factor recognizes human FGF-7. This antibody shows less than 20% cross-reactivity with human FGF-9 and less than 10% cross-reactivity with human FGF-4.
Immunogen
recombinant human keratinocyte growth factor (FGF-7) expressed in E. coli.
Application
Anti-keratinocyte growth factor antibody may be used to neutralize the biological activity of human KGF at a neutralization dose of ~6-12 μg/ml. The recommended concentration for immunoblotting is 0.1-0.2 μg/ml. For ELISA, a working antibody concentration of 0.5-1.0 μg/ml may be used. Immunohistochemistry of formalin-fixed, paraffin-embedded sections may be performed using a concentration of 15 μg/ml.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Paul W Finch et al.
Journal of the National Cancer Institute, 98(12), 812-824 (2006-06-22)
Keratinocyte growth factor (KGF) is a locally acting epithelial mitogen that is produced by cells of mesenchymal origin and has an important role in protecting and repairing epithelial tissues. Use of recombinant human KGF (palifermin) in patients with hematologic malignancies
Uzma Athar et al.
Expert opinion on biological therapy, 9(6), 779-787 (2009-05-22)
Mucositis occurs in over 90% of patients undergoing stem cell transplantation for hematological malignancies. It is associated with significant morbidity in the form of pain, dysphagia and decreased oral intake, as well as mortality. Palifermin is a recombinant keratinocyte growth
Prabir Ray
Proceedings of the American Thoracic Society, 2(3), 221-225 (2005-10-14)
Oxidative injury to the lung is associated with widespread injury to the alveolar epithelium, which can be fatal unless the process is controlled and repaired. Keratinocyte growth factor (KGF), a member of the fibroblast growth factor family, has been shown
Paul W Finch et al.
Advances in cancer research, 91, 69-136 (2004-08-26)
Keratinocyte growth factor (KGF) is a paracrine-acting, epithelial mitogen produced by cells of mesenchymal origin. It is a member of the fibroblast growth factor (FGF) family, and acts exclusively through a subset of FGF receptor isoforms (FGFR2b) expressed predominantly by
P W Finch et al.
Science (New York, N.Y.), 245(4919), 752-755 (1989-08-18)
Keratinocyte growth factor (KGF) is a human mitogen that is specific for epithelial cells. The complementary DNA sequence of KGF demonstrates that it is a member of the fibroblast growth factor family. The KGF transcript was present in stromal cells
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