K3143
PAK4, active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
recombinant
expressed in baculovirus infected Sf9 cells
Quality Level
product line
PRECISIO® Kinase
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
61-83 nmol/min·mg
mol wt
~90 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PAK4(10298)
Biochem/physiol Actions
PAK4 (p21 protein (Cdc42/Rac)-activated kinase 4) belongs to the group 2 PAKs, which also include PAK5 and PAK6.[1] Unlike other PAK proteins, PAK4 has strong association with CDC42 (cell division cycle 42) but has weak interaction with RAC (AKT1, v-akt murine thymoma viral oncogene homolog 1). It is a connection between CDC42 and filopodium formation. It regulates CDC42-induced anchorage-independent growth.[2]
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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J Qu et al.
Molecular and cellular biology, 21(10), 3523-3533 (2001-04-21)
The serine/threonine kinase PAK4 is an effector molecule for the Rho GTPase Cdc42. PAK4 differs from other members of the PAK family in both sequence and function. Previously we have shown that an important function of this kinase is to
Zahara M Jaffer et al.
The international journal of biochemistry & cell biology, 34(7), 713-717 (2002-04-16)
The p21-activated kinases (Paks) are serine/threonine protein kinases that bind to and, in some cases, are stimulated by activated forms of the small GTPases, Cdc42 and Rac. With the recent discovery of several novel isoforms, Paks are now categorized into
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