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K1390

Sigma-Aldrich

Monoclonal Anti-hKid antibody produced in mouse

~1 mg/mL, clone 8C12, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-Kinesin-like 4, KNSL4, Anti-Kinesin-like DNA-binding protein, Anti-OBP ORIP-binding protein, Anti-Origin of plasmid DNA replication-binding protein

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About This Item

MDL number:
MFCD02262549
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

8C12, monoclonal

form

buffered aqueous solution

mol wt

antigen ~65 kDa

species reactivity

human

packaging

antibody small pack of 25 μL

concentration

~1 mg/mL

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: 1-2 μg/mL using HeLa total cell extract

isotype

IgG1

UniProt accession no.

Q14807

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... KIF22(3835)

General description

The gene KIF22 (kinesin family member 22) encodes a kinesin-like protein family member that is found to be expressed in human bone, cartilage, joint capsule, ligament, skin, and primary cultured chondrocytes. The gene is mapped to human chromosome 16p11.2.

Immunogen

purified human hKid.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

Kinesins hydrolyze ATP to generate energy for molecular motors. The gene KIF22 (kinesin family member 22) encodes a chromokinesin that has the ability to bind to both DNA and microtubules. This mitotic motor protein functions in spindle assembly and proper chromosome segregation during mitosis. It is found to be associated with Chfr (check point protein with FHA (forkhead-associated domain) and RING domains), a ubiquitin-protein isopeptide E3 ligase that is crucial for the control of early mitotic checkpoint.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium axide.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
048K4802

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Cornelia Wandke et al.
Hybridoma (2005), 25(1), 41-43 (2006-02-16)
Chromokinesins are chromosome-bound proteins during mitosis that play multiple important roles in chromosome segregation. The chromokinesin Kid has been shown to be involved in chromosome congression during mitosis and meiosis. Here we have generated a monoclonal antibody specific for the
Whole-exome sequencing identifies mutations of KIF22 in spondyloepimetaphyseal dysplasia with joint laxity, leptodactylic type.
Min BJ
American Journal of Human Genetics, 89, 760-766 (2011)
Obstetric ultrasonography: the placenta.
Kennedy A
Abdominal Imaging, 22, 602-610 (1997)
Alicia Blaker-Lee et al.
Disease models & mechanisms, 5(6), 834-851 (2012-05-09)
Deletion or duplication of one copy of the human 16p11.2 interval is tightly associated with impaired brain function, including autism spectrum disorders (ASDs), intellectual disability disorder (IDD) and other phenotypes, indicating the importance of gene dosage in this copy number

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