K1014
Anti-Kinesin 5B antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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About This Item
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, human
technique(s)
western blot: 0.5 μg/mL using mouse neuronal cell extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... KIF5B(3799)
mouse ... Kif5b(16573)
General description
The gene KIF5B (kinesin 5B) is mapped to human chromosome 10p11.22. It encodes a conventional kinesin that contains two heavy chains and two light chains forming a heterotetramer. It is abundantly expressed in adipocytes.
Immunogen
synthetic peptide corresponding to amino acid residues 376-396 from human kinesin 5B.
Application
Anti-Kinesin 5B antibody produced in rabbit has been used in immunoprecipitation.[1]
Biochem/physiol Actions
The gene KIF5B (kinesin 5B) encodes a kinesin that is involved in the transportation of GLUT4 (glucose transporter protein) to the plasma membrane in response to insulin, thereby regulating insulin signaling pathway. It participates in the translocation of certain apical proteins to the apical membrane.
Physical form
Solution in phosphate buffered saline containing 1 mg/mL BSA and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Polarization-dependent selective transport to the apical membrane by KIF5B in MDCK cells.
Jaulin F
Developmental Cell, 13, 511-522 (2007)
A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing.
Ju YS
Genome Research, 22, 436-445 (2012)
Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules.
Semiz S
The Embo Journal, 22, 2387-2399 (2003)
Raed Hanania et al.
The Journal of biological chemistry, 287(11), 8468-8483 (2012-01-25)
As major effector cells of the innate immune response, macrophages must adeptly migrate from blood to infected tissues. Endothelial transmigration is accomplished by matrix metalloproteinase (MMP)-induced degradation of basement membrane and extracellular matrix components. The classical activation of macrophages with
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