Neuroprotective and cognition-enhancing (nootropic) benzothiazole derivative that prevents NMDA- and glutamate-induced neurotoxicity.
Sabeluzole is a benzothiazole derivative that exerts neuroprotective and cognition-enhancing (nootropic) efficacy by preventing NMDA- and glutamate-induced neurotoxicity.
Basic research in cardiology, 84(5), 489-498 (1989-09-01)
In the guinea pig heart-lung preparation, the protective effects of nifedipine and R 58735 on cardiovascular alterations following mild (35 min) and severe (60 min) ischemia and reperfusion (30 min) were studied. Nifedipine and R 58735 were equi-protective against the
Synapse (New York, N.Y.), 12(4), 271-280 (1992-12-01)
The neuroprotective properties of the cognitive enhancer sabeluzole were investigated in rat brain neuronal cultures derived from the hippocampal formation of 17-day-old rat embryos. Measurement of the neuronal cytoskeletal microtubule-associated protein, MAP2, was used to assess survival of neurons after
The memory enhancing properties of sabeluzole nad flunarizine were evaluated in two experimental paradigms in male rats. First, we studied the protective action of both drugs against a chlordiazepoxide-induced impairment of habituation. Sabeluzole (5 or 25 mg/kg) or flunarizine (10
Unilateral photochemical infarcts were produced in the hind limb sensorimotor neocortex of 243 rats by intravenous injection of the fluorescein derivative Rose Bengal and focal illumination of the intact skull surface. Facial contact stimuli governed the degree and recovery rate
Biulleten' eksperimental'noi biologii i meditsiny, 88(11), 560-563 (1979-11-01)
The effect of gamma-hydroxybutyric acid (GHBA) on the extracellularly registered spontaneous electrical activity of nervous cells of the rabbit brain sensomotor cortex was studied using the microionophoretic technique. GHBA decreased the frequency of action potential in the majority of the
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