The Janus kinases (JAKs) are protein tyrosine kinases that modulate cytokine signaling during immunological responses and hematopoiesis. JAK family members consist of four isoforms, namely, JAK1, JAK2, JAK3 and TYK2. JAK1 plays a crucial role in mediating the JAK/STAT signaling response to interleukin 6. Alterations in JAK functions have been implicated in heart and immunological disorders, as well as in hematopoietic malignancies . Monoclonal Anti-JAK1 antibody is specific for human JAK1 (approx. 130 kDa).
Immunogen
The peptide sequence is identical in mouse and rat JAK1.
synthetic peptide corresponding to amino acids 543-555 of human JAK1, conjugated to KLH
Application
Monoclonal Anti-JAK1 antibody is suitable for use in western blot (2-4 μg/mL using extract from Raji cells), indirect ELISA and microarray.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium aside.
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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Seminars in cell & developmental biology, 19(4), 385-393 (2008-08-07)
The four mammalian Janus kinase (JAK) family members, JAK1, JAK2, JAK3 and TYK2, are non-receptor protein tyrosine kinases (PTKs) that are crucial for cytokine receptor signaling in blood formation and immune responses. Mutations and translocations in the JAK genes leading
Journal of molecular biology, 387(1), 219-232 (2009-04-14)
The Janus kinases (JAKs) are a pivotal family of protein tyrosine kinases (PTKs) that play prominent roles in numerous cytokine signaling pathways, with aberrant JAK activity associated with a variety of hematopoietic malignancies, cardiovascular diseases and immune-related disorders. Whereas the
The protein tyrosine kinases JAK1, JAK2 and Tyk2 and STATs (signal transducers and activators of transcription) 1 and 3 are activated in response to interleukin-6 (IL-6) in human fibrosarcoma cells. In mutant cells lacking JAK1, JAK2 or Tyk2, the absence
Journal of biochemical and molecular toxicology, 35(10), e22882-e22882 (2021-09-25)
Human cervical cancer is the fourth most common carcinoma in women in the world. The JAK/STAT3 signaling pathways crucially regulate cell growth and apoptosis. It is a significant target signaling pathway for the development of novel antitumor medicine. This study
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