J3253

Monoclonal Anti-Junctional Sarcoplasmic Reticulum Protein antibody produced in mouse

clone VF1C, diluted ascites fluid

• MDL number: MFCD02263551
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• Quality Level: 200
• conjugate: unconjugated
• antibody form: diluted ascites fluid
• antibody product type: primary antibodies
• clone: VF1C, monoclonal
• mol wt: antigen 90 kDa
• species reactivity: canine, guinea pig, rabbit, rat, mouse
• technique(s): indirect immunofluorescence: suitable; western blot: suitable
• UniProt accession no.: Q3MI48
• shipped in: dry ice
• Storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: mouse ... Jsrp1(71912)

Description

General description

The gene Jsrp1 (junctional sarcoplasmic reticulum protein 1), also referred to as JP45, encodes an integral protein that contains a predicted cytoplasmic domain, an intralumenal domain that is rich in positively charged amino acids, preceded by a single transmembrane segment. The mRNA has been detected in 17-day-old mouse embryos, with increased expression during the second month of postnatal development. Its expression decreases 3-fold during aging. The protein is localized to the junctional sarcoplasmic reticulum.

Immunogen

rabbit skeletal muscle triads.

Biochem/physiol Actions

The gene Jsrp1 (junctional sarcoplasmic reticulum protein 1) encodes an integral protein component of the junctional face membrane of the skeletal muscle sarcoplasmic reticulum. It is found to associate with Ca_v1.1 (voltage-dependent Ca²⁺ channel) and calsequestrin, a luminal Ca²⁺-binding protein. The complex formed by Jsrp1 and Cav1.1 is found to be decreased with age and has been linked to decayed muscle strength and physical disability in the elderly. Knock-out of this gene in young mice results in decreased expression of Ca_v1.1 and diminished muscle strength.

Physical form

Solution in phosphate buffered saline containing 0.05% sodium azide.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)