I9029
Insulin-like Growth Factor Binding Protein-6 human
>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
Synonym(s):
IGFBP-6
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About This Item
MDL number:
UNSPSC Code:
12352202
biological source
human
recombinant
expressed in NSO cells
assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
0.35 μg/mL ED50
mol wt
34 kDa by SDS-PAGE (reducing)
calculated mol wt 23 kDa
packaging
pkg of 25 μg
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IGFBP6(3489)
General description
The gene IGFBP-6 (insulin-like growth factor binding protein-6) is mapped to human chromosome 12q13.[1]
Biochem/physiol Actions
IGFBP-6 (insulin-like growth factor binding protein-6) works as a tumor suppressor for nasopharyngeal carcinoma and also suppresses prostate cancer cell proliferation.[2]
Insulin-like growth factor binding protein found in cerebrospinal fluid and serum; exhibits 2-fold higher affinity for IGF-II than for IGF-I.
Physical form
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA.
Analysis Note
The biological activity is measured by its ability to inhibit the biological activity of recombinant human IGF-II on MCF-7 cells.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Yong Xu et al.
The Tohoku journal of experimental medicine, 233(1), 25-31 (2014-04-22)
Prostate cancer (PCa) is the second leading cause of cancer-related death in men globally. However, there are few sensitive biomarkers for PCa, especially those which can distinguish PCa and benign prostate hyperplasia (BPH). Antibody microarrays allow for high-throughput and high-sensitivity
Amir Ali Abbasi et al.
BMC evolutionary biology, 7, 239-239 (2007-12-07)
The human chromosomes 2q, 7, 12q and 17q show extensive intra-genomic homology, containing duplicate, triplicate and quadruplicate paralogous regions centered on the HOX gene clusters. The fact that two or more representatives of different gene families are linked with HOX
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