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I8783

Sigma-Aldrich

Anti-Interleukin-19 antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-IL-19

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About This Item

MDL number:
MFCD06798465
UNSPSC Code:
51111800
NACRES:
NA.41

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

flow cytometry: 3-10 μg/mL (106 cells)
indirect ELISA: 0.5-1.0 μg/mL
western blot: 0.1-0.2 μg/mL

UniProt accession no.

Q9UHD0

Storage temp.

−20°C

Gene Information

human ... IL19(29949)

General description

Interluekin-19 (IL-19) is a member of IL-10 family of cytokines. It is highly homologous to IL-20 and IL-24 and shares a heterodimeric receptor, formed by IL-20Rα and IL-20Rβ subunits. IL-19 is produced by B cells, macrophages, keratinocytes and epithelial cells. The secretion of IL-19 is induced by TLR4 signalling pathway in response to LPS. IL-19 mediates the activation of NF-κB, STAT1, STAT3 and MAPK pathways. The major function of IL-19 is the regulation of production of inflammatory cytokines. It controls the innate myeloid cell response to pathogenic microbes and is crucial for endotoxin tolerance in activated macrophages. IL-19 has a potential immunomodulatory role in chronic inflammatory diseases, asthma and psoriasis
Anti-Interleukin-19 detects human interleukin 19.

Immunogen

purified, E. coli-derived, recombinant human mature interleukin 19.

Application

Anti-Interleukin-19 antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml. For ELISA a concentration of 0.5-1.0 μg/ml is recommended. The antibody is also suitable for flow cytometry at a working antibody concentration of 3-10 μg/ml/106 cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

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Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
084K0902

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Grant Gallagher
Cytokine & growth factor reviews, 21(5), 345-352 (2010-10-05)
First reported in 1999, IL-19 remains a mystery in many ways. Despite appearing in many genome scans and candidate gene studies, and having been searched for specifically as part of the IL-10 family, its function is still to be defined.
Yasu-Taka Azuma et al.
Journal of pharmacological sciences, 115(2), 105-111 (2010-12-16)
The cytokine, interleukin (IL)-19, is a member of the IL-10 family that includes IL-20, IL-22, IL-24, and IL-26. Recent studies have shown that IL-19 is produced by keratinocytes, epithelial cells, macrophages, and B-cells. Little is known about the exact biological
Interleukin-19 (IL-19) network revisited.
D Kempuraj et al.
International journal of immunopathology and pharmacology, 16(2), 95-97 (2003-06-12)
Alexander Zdanov
Vitamins and hormones, 74, 61-76 (2006-10-10)
The interleukin-19 (IL-19) subfamily of cytokines is part of a larger family of homologs of IL-10 that includes two groups of proteins: five viral cytokines, and eight cellular cytokines, having quite different biological activities. Among proteins of the latter group

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