I8153
Anti-Interleukin-1 Receptor Accessory Protein antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-IL-1RAcP
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About This Item
MDL number:
UNSPSC Code:
51111800
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 66 kDa
species reactivity
mouse, rat, human
technique(s)
western blot: 0.5 μg/mL using human HeLa cell extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... IL1RAP(3556)
mouse ... Il1rap(16180)
rat ... Il1rap(25466)
General description
Interleukin-1 is a proinflammatory cytokine produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that exert their cellular effects by signaling through IL-1 receptor type 1 (IL-1R1). IL-1 recruits Interleukin-1 Receptor Accessory Protein (IL-1RAcP) that stabilizes the ligand-receptor association. IL-1RAcP is expressed by astrocytes and neurons in the brain. IL-1RAcP does not regulate the responses of IL-1 directly but modulates the gene expression and inflammatory responses induced by IL-1. IL-1RAcP is critical in mediating the activation of IRAK and SAPK pathways by IL-1. Anti-Interleukin-1 Receptor Accessory Protein antibody recognizes human, mouse and rat IL-1RAcP (~66 kDa). There is no cross-reactivity to other members in the IL-1 and IL-18 receptor families.
Immunogen
synthetic peptide corresponding to amino acids 525-540 of human Interleukin-1 Receptor Accessory Protein (Il-1RAcP). This sequence is identical in mouse and rat.
Application
Anti-Interleukin-1 Receptor Accessory Protein antibody is suitable for immunoblotting at a working concentration of 0.5 μg/ml using HeLa cell extract.
Physical form
Solution in phosphate buffered saline, containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Adam Denes et al.
Cerebrovascular diseases (Basel, Switzerland), 32(6), 517-527 (2011-11-23)
Inflammation is established as a contributor to cerebrovascular disease. Risk factors for stroke include many conditions associated with chronic or acute inflammation, and inflammatory changes in the brain after cerebrovascular events contribute to outcome in experimental studies, with growing evidence
Interleukin-1, inflammasomes, autoinflammation and the skin
Contassot E et al
Swiss Medical Weekly, 142, w13590-w13590 (2010)
H Wesche et al.
The Journal of biological chemistry, 272(12), 7727-7731 (1997-03-21)
Interleukin-1 (IL-1) is a central mediator of the immune system involved in acute and chronic inflammatory responses. Although the sequences of two types of IL-1 receptors are known, the exact molecular events resulting in signal transduction and coupling to downstream
Axel Weber et al.
Science signaling, 3(105), cm1-cm1 (2010-01-21)
The interleukin-1 (IL-1) family of cytokines comprises 11 proteins (IL-1F1 to IL-1F11) encoded by 11 distinct genes in humans and mice. IL-1-type cytokines are major mediators of innate immune reactions, and blockade of the founding members IL-1alpha or IL-1beta by
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