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I7892

Sigma-Aldrich

Anti-Interferon-γ Inducible Protein antibody produced in goat

IgG fraction of antiserum, lyophilized powder

Synonym(s):

Anti-IP-10

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About This Item

Beilstein/REAXYS Number:
4294860
MDL number:
MFCD01092385
UNSPSC Code:
51111800
NACRES:
NA.41

biological source

goat

Quality Level

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P02778

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CXCL10(3627)

General description

Interferon-γ Inducible Protein (IP-10), also known as CXCL-10, is a cytokine that belongs to the CXC chemokine family. It is secreted in response to interferon-γ by neutrophils, monocytes, basophils, epithelial cells and keratinocytes. IP-10 is involved in chemotaxis, apoptosis, angiostasis and inhibits cell growth. The effects of IP-10 are mediated by its receptor, CXCR3. The major signalling pathways that are activated by IP-10 are those of MAPK, PKA, JNK, NF-κB and PI3K/Akt. Alteration of IP-10 levels has been observed in various infectious diseases caused bacteria, fungi and viruses such as dengue, Ebola and hepatitis B
Anti-Interferon-γ Inducible Protein antibody detects human IP-10.

Immunogen

recombinant human IP-10.

Application

Anti-Interferon-γ Inducible Protein antibody may be used for immunoblotting at a working antibody concentration of 1-2 μg/ml. For ELISA, antibody concentration of 0.5-1.0 μg/ml is recommended.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose

Preparation Note

Purified using protein G.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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Morten Ruhwald et al.
Expert review of molecular diagnostics, 12(2), 175-187 (2012-03-01)
The current state-of-the-art tests for infection with Mycobacterium tuberculosis - the IFN-γ release assays - rely on accurate measurement of the cytokine IFN-γ. Many other potential biomarkers are expressed in concert with IFN-γ, and IP-10 in particular has shown promising
Mig and IP-10: CXC chemokines that target lymphocytes
Farber JM
Journal of Lipid Research, 61, 246-257 (1997)
Mingli Liu et al.
Cytokine & growth factor reviews, 22(3), 121-130 (2011-08-02)
C-X-C motif chemokine 10 (CXCL10) also known as interferon γ-induced protein 10 kDa (IP-10) or small-inducible cytokine B10 is a cytokine belonging to the CXC chemokine family. CXCL10 binds CXCR3 receptor to induce chemotaxis, apoptosis, cell growth and angiostasis. Alterations

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