The gene ITPR2 (Inositol 1,4,5-Triphosphate Receptor type 2) encodes type 2 intracellular receptor that binds to Inositol 1,4,5 trisphosphate. The gene encodes a 2701 amino acid protein that contains six membrane-spanning regions near the C-termini. The cytoplasmic N-terminal domain is involved in ligand-binding. The gene is mapped to human chromosome 12p11.
Immunogen
synthetic petide with a sequence derived from the cytoplasmic, amino-terminus of rat IP3R-II.
Biochem/physiol Actions
The receptor encoded by the gene ITPR2 (Inositol 1,4,5-Triphosphate Receptor type 2) is a Ca2+ release channel in the endoplasmic reticulum that is stimulated upon binding to its ligand inositol 1,4,5-triphosphate. It mediates intracellular calcium signaling. It facilitates the release of Ca2+ from endoplasmic reticulum and modulates intracellular Ca2+ concentration. Loss of ITPR2 gene function is found to be associated with anhidrosis and can inhibit sweat production in humans and mice.
Physical form
Solution in PBS with 1.0 mg/ml bovine serum albumin and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The Biochemical journal, 334 ( Pt 3), 559-563 (1998-09-08)
We have found a novel isoform of the mouse type 2 Ins(1,4,5)P3 receptor [Ins(1,4,5)P3R] mRNA by reverse transcriptase-mediated PCR analysis. The novel isoform, which was expressed specifically in skeletal muscle and heart, was generated by the inclusion of a novel
We have cloned cDNAs coding for human type 2 and type 3 and part of type 1 inositol 1,4,5-trisphosphate receptors (IP3Rs). The complete nucleotide sequences for type 2 and type 3 receptors were determined and the pharmacological properties of the
The Journal of clinical investigation, 124(11), 4773-4780 (2014-10-21)
There are 3 major sweat-producing glands present in skin; eccrine, apocrine, and apoeccrine glands. Due to the high rate of secretion, eccrine sweating is a vital regulator of body temperature in response to thermal stress in humans; therefore, an inability
Questions
Reviews
★★★★★ No rating value
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
