immunocytochemistry: 8-25 μg/mL using using human PBMCs immunohistochemistry (frozen sections): 8-25 μg/mL using using human tissue neutralization: suitable western blot: 1 μg/mL (under non-reducing conditions)
recombinant human IL-2 soluble receptor alpha (IL-2 Rα), expressed in Sf 21 insect cells.
Biochem/physiol Actions
Interleukin-2 (IL-2) is a cytokine produced by activated T cells in response to antigen stimulation. The effects of IL-2 are mediated by the signaling activated by its binding to IL-2 receptor (IL-2 R). IL-2 activates key signaling pathways such as MAPK, JAK/STAT as well as PI3K/Akt. Activation of these pathways modulates production of inflammatory cytokines, survival and progression through cell cycle.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline wth 5% trehalose.
Preparation Note
Purified using protein A.
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Studies of the biology of the IL-2 receptor have played a major part in establishing several of the fundamental principles that govern our current understanding of immunology. Chief among these is the contribution made by lymphokines to regulation of the
Interleukin-2 (IL-2) has multiple, sometimes opposing, functions during an inflammatory response. It is a potent inducer of T-cell proliferation and T-helper 1 (Th1) and Th2 effector T-cell differentiation and provides T cells with a long-lasting competitive advantage resulting in the
Recent work has identified a new subset of effector T cells that produces interleukin (IL)-17 known as T helper 17 (Th17) cells, which is involved in the pathophysiology of inflammatory diseases and is thought to be developmentally related to regulatory
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