I5528
Interferon-Inducible T Cell α Chemoattractant human
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(s):
β-R1, H174, I-TAC, SCYB9B
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Recommended Products
biological source
human
Quality Level
recombinant
expressed in E. coli
assay
≥97% (SDS-PAGE)
form
lyophilized powder
potency
10-20 ng/mL ED50
mol wt
8.3 kDa
packaging
pkg of 25 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1ng/mg
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... CXCL11(6373)
Biochem/physiol Actions
I-TAC (Interferon-inducible T-cell α chemoattractant) is a chemokine which participates in recruitment of inflammatory cell. It binds to receptor CXCR3 (C-X-C motif chemokine receptor 3). I-TAC is associated with the severity of dengue.
Physical form
Lyophilized in 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg of bovine serum albumin.
Analysis Note
The biological activity is measured by its ability to induce chemotaxis in IL-2 cultured human lymphocytes.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
B P Hoh et al.
Human immunology, 76(6), 421-426 (2015-04-11)
Dengue causes significantly more human disease than any other arboviruses. It causes a spectrum of illness, ranging from mild self-limited fever, to severe and fatal dengue hemorrhagic fever, as evidenced by vascular leakage and multifactorial hemostatic abnormalities. There is no
D P Widney et al.
Journal of immunology (Baltimore, Md. : 1950), 164(12), 6322-6331 (2000-06-08)
A new murine chemokine was identified in a search for glucocorticoid-attenuated response genes induced in the lung during endotoxemia. The first 73 residues of the predicted mature peptide are 71% identical and 93% similar to human CXCL11/IFN-inducible T cell alpha
Y Luo et al.
Journal of neurovirology, 4(6), 575-585 (1999-03-05)
H174 is a new member of the CXC-chemokine family. A cDNA probe containing the entire H174 coding region recognized a predominant inducible transcript of approximately 1.5 kb expressed in interferon (IFN) activated astrocytoma and monocytic cell lines. H174 message can
R Krishnan Kutty et al.
Cytokine, 74(2), 335-338 (2015-04-22)
Dysfunction of the retinal pigment epithelium (RPE) resulting from chronic inflammation is implicated in the pathogenesis of age-related macular degeneration (AMD). RPE cells adjacent to drusen deposits in the AMD eye are known to contain CXCL11, a chemokine involved in
K E Cole et al.
The Journal of experimental medicine, 187(12), 2009-2021 (1998-06-24)
Chemokines are essential mediators of normal leukocyte trafficking as well as of leukocyte recruitment during inflammation. We describe here a novel non-ELR CXC chemokine identified through sequence analysis of cDNAs derived from cytokine-activated primary human astrocytes. This novel chemokine, referred
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service