I5527
Monoclonal Anti-Interleukin-1 Soluble Receptor Type I antibody produced in mouse
clone 35730, purified immunoglobulin, lyophilized powder
Synonym(s):
Anti-IL-1 sRI
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About This Item
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
35730, monoclonal
form
lyophilized powder
species reactivity
human
technique(s)
capture ELISA: 2-8 μg/mL
western blot: 1 μg/mL
isotype
IgG1
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IL1R1(3554)
General description
Interleukin 1 (IL-1) is a cytokine responsible for the regulation of inflammation and immune responses. Interleukin-1 Receptor Type I is a 80kD protein found on many cells like monocytes, NK cells, T cells, B cells, fibroblasts, dendritic cells, endothelial cells, vascular endothelial cells, neural cells, basophils, neutrophils and eosinophils. It has a pivotal role in signal transduction, where IL-1 Receptor Type I binds with interleukin-1 and the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex that facilitates IL-1 dependent activation of NF-κ-B, MAPK and other pathways. Monoclonal anti-Interleukin-1 Soluble Receptor Type I antibody can be used in western blotting. Mouse anti-Interleukin-1 Soluble Receptor Type I antibody reacts specifically with human IL-1 Receptor I. The product has shown no cross-reactivity with recombinant human IL-1 ra, recombinant human IL-1 RII, recombinant human IL-1 RacP (IL-1 R3), recombinant human IL-1 R5, recombinant human IL- 1 R6 or recombinant mouse IL-1 RI.
Immunogen
recombinant human IL-1 sRI expressed in Sf 21 cells.
Application
Monoclonal anti-Interleukin-1 Soluble Receptor Type I antibody can be used as a capture antibody in a sandwich ELISA.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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J L Slack et al.
The Journal of biological chemistry, 275(7), 4670-4678 (2000-02-15)
Type I interleukin-1 receptor is the prototype for a family of proteins, which play a central role in early responses to injury and infection. The similarity of function across the family is reflected in similarity in signaling: all members tested
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