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Key Documents

I4638

Sigma-Aldrich

Interleukin-1β Fragment 163-171 human

≥97% (HPLC), synthetic

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About This Item

Empirical Formula (Hill Notation):
C39H64N12O19
CAS Number:
Molecular Weight:
1004.99
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:

biological source

synthetic

assay

≥97% (HPLC)

form

powder

mol wt

Mw 1004.99

packaging

pkg of 1 mg

color

white

solubility

water: soluble 1 mg/mL, clear, colorless

UniProt accession no.

storage temp.

−20°C

SMILES string

CC(C)[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(O)=O

InChI

1S/C39H64N12O19/c1-17(2)31(43)38(68)47-18(6-9-25(41)53)32(62)44-15-27(55)45-19(7-10-28(56)57)33(63)46-20(8-11-29(58)59)34(64)51-24(16-52)37(67)49-22(13-26(42)54)35(65)50-23(14-30(60)61)36(66)48-21(39(69)70)5-3-4-12-40/h17-24,31,52H,3-16,40,43H2,1-2H3,(H2,41,53)(H2,42,54)(H,44,62)(H,45,55)(H,46,63)(H,47,68)(H,48,66)(H,49,67)(H,50,65)(H,51,64)(H,56,57)(H,58,59)(H,60,61)(H,69,70)/t18-,19-,20-,21-,22-,23-,24-,31-/m0/s1

InChI key

NIXBZDOQHRZFDR-OEWCNXHOSA-N

Gene Information

human ... IL1B(3553)

Amino Acid Sequence

Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys

Biochem/physiol Actions

IL1B (interleukin 1 β) is an immune-activating cytokine. In presence of infection or cell stress, it gets converted into active mature form.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Angelia D Lockett et al.
American journal of respiratory cell and molecular biology, 49(1), 143-150 (2013-03-26)
α₁-Antitrypsin (A1AT) is an acute-phase reactant, but also a major protective factor against the development of chronic obstructive pulmonary disease, a complex disease with sustained chronic inflammation. The lung-protective effects of A1AT have been attributed to the inhibition of proteases
William J Trickler et al.
Nanomedicine (London, England), 7(6), 835-846 (2012-02-22)
The purpose of the current study was to determine whether copper nanoparticles (Cu-NPs) can induce the release of proinflammatory mediators that influence the restrictive characteristics of the blood-brain barrier. Confluent rat brain microvessel endothelial cells (rBMECs) were treated with well-characterized
L Nencioni et al.
Journal of immunology (Baltimore, Md. : 1950), 139(3), 800-804 (1987-08-01)
The stimulating effect of a synthetic nonapeptide (fragment 163-171) of human interleukin 1 beta (IL-1 beta) on antibody responses to both T helper-dependent and T helper-independent antigens was investigated. It was shown that the nonapeptide enhanced the antibody response, as
Anna K Blakney et al.
Journal of biomedical materials research. Part A, 100(6), 1375-1386 (2012-03-13)
Poly(ethylene glycol) (PEG) hydrogels, modified with RGD, are promising platforms for cell encapsulation and tissue engineering. While these hydrogels offer tunable mechanical properties, the extent of the host response may limit their in vivo applicability. The overall objective was to
Shane M Huebner et al.
The Journal of nutrition, 140(8), 1454-1461 (2010-06-25)
Previously, dietary conjugated linoleic acid [(CLA), an equal mixture of cis-9, trans-11 (c9t11) and trans-10, cis-12 (t10c12) CLA isomers], was found to reduce inflammation in the murine collagen antibody-induced arthritis model, but less so in the murine collagen-induced arthritis (CIA)

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