I4532
Monoclonal Anti-Interleukin-13 antibody produced in rat
clone 38213.11, purified immunoglobulin, lyophilized powder
Synonym(s):
Anti-IL-13
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About This Item
MDL number:
UNSPSC Code:
51111800
biological source
rat
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
38213.11, monoclonal
form
lyophilized powder
species reactivity
mouse
technique(s)
capture ELISA: suitable
neutralization: suitable
western blot: 1-2 μg/mL
isotype
IgG2b
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
mouse ... Il13(16163)
General description
Interleukin-13 (IL-13) is a cytokine produced by Th2 cells and mediates the production of immunoglobulins, B cell proliferation and differentiation of cells of the monocytic lineage. The interaction of IL-13 with its receptor triggers responses via the STAT-6 pathway and results in antibody-mediated responses, eosinophil recruitment in lungs, airway remodelling, mucus overproduction, secretion of matrix metalloproteinases (MMP)-9 and MMP-12 and IgE production. The other signaling axis that is mediated by IL-13 is the EGFR-TGF-α pathway that induces proliferation of epithelial cells. Elevated IL-13 has been associated with the symptoms of asthma and is detected in elevated levels in the airways and sputum of asthma patients
Monoclonal Anti-Mouse Interleukin-13 recognizes recombinant mouse IL-13.
Monoclonal Anti-Mouse Interleukin-13 recognizes recombinant mouse IL-13.
Specificity
The biological activity is measured by its ability to neutralize recombinant mouse IL-13.
Immunogen
purified recombinant mouse IL-13 expressed in E. coli.
Application
Monoclonal anti-mouse interleukin-13 may be used in neutralization assays at a working concentration range of 03.-0.8 μg/ml. For immunoblotting a concentration of 1-2 μg/ml may be used. For ELISA a working concentration of 2-4 μg/ml is recommended.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Regulation of IL-13 production by histamine in cloned murine T helper type 2 cells
Elliott, KA et al
Immunopharmacology, 1, 1923-1937 (2001)
Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma
Oh CK et al
European Respiratory Review, 19, 11546-11554 (2010)
Interleukin-13 and leukotrienes: an intersection of pathogenetic schema.
Jack A Elias et al.
American journal of respiratory cell and molecular biology, 28(4), 401-404 (2003-03-26)
C G Lee et al.
The Journal of experimental medicine, 194(6), 809-821 (2001-09-19)
Interleukin (IL)-13 is a key mediator of tissue fibrosis caused by T helper cell type 2 inflammation. We hypothesized that the fibrogenic effects of IL-13 are mediated by transforming growth factor (TGF)-beta. To test this hypothesis we compared the regulation
A N McKenzie et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(8), 3735-3739 (1993-04-15)
We have isolated the human cDNA homologue of a mouse helper T-cell-specific cDNA sequence, called P600, from an activated human T-cell cDNA library. The human cDNA encodes a secreted, mainly unglycosylated, protein with a relative molecular mass of approximately 10,000.
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