I3157
Monoclonal Anti-Interleukin-9 Receptor antibody produced in mouse
clone 33423.111, purified immunoglobulin, lyophilized powder
Synonym(s):
Anti-CD129, Anti-IL-9 Receptor
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About This Item
MDL number:
UNSPSC Code:
51111800
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
33423.111, monoclonal
form
lyophilized powder
species reactivity
human
technique(s)
indirect ELISA: 0.5-1.0 μg/mL
neutralization: suitable
western blot: 1-2 μg/mL
isotype
IgG1
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IL9R(3581)
General description
Interleukin-9 (IL-9) is a pleotropic cytokine produced by activated T cells and also by mast cells in response to LPS and IL-1. The biological effects of IL-9 are mediated by IL-9 receptor (IL-9R) that is made up of an α and a γ chain. The expression of IL-9R is restricted to effector T cells, mast cells and few non-hematopoietic cells. IL-9R signalling results in the activation of major signalling pathways involving STAT1, -3 and -5, MAPK, PI3K and IRS. IL-9R signalling is pro-inflammatory and promotes allergic inflammation and airway remodelling in lungs. It also is important in cell growth and differentiation of T cells, B cells, mast cells, hematopoietic progenitors, epithelial cells and airway smooth muscle cells
Monoclonal Anti-Human Interleukin-9 Receptor recognizes human IL-9 R (26 kDA, observed molecular mass approximately 29 kDa as a result of glycosylation).
Monoclonal Anti-Human Interleukin-9 Receptor recognizes human IL-9 R (26 kDA, observed molecular mass approximately 29 kDa as a result of glycosylation).
Specificity
The antibody blocks the cell surface human IL-9 receptor mediated biological activities induced by recombinant human IL-9.
Immunogen
purified recombinant human soluble IL-9 receptor, expressed in Sf 21 insect cells.
Application
Anti-Interleukin-9 receptor antibody may be used for immunoblotting at a working concentration of 1.0-2.0 μg/ml. For ELISA a concentration of 0.5-1.0 μg/ml is recommended. The antibody is also suitable for neutralization reactions (ND50 is 2-4 μg/ml).
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose.
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Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Ritobrata Goswami et al.
Journal of immunology (Baltimore, Md. : 1950), 186(6), 3283-3288 (2011-03-04)
IL-9 was first described in the late 1980s as a member of a growing number of cytokines that had pleiotropic functions in the immune system. Although many biological functions have been attributed to IL-9, it remains an understudied cytokine. A
Jennifer Kearley et al.
American journal of respiratory and critical care medicine, 183(7), 865-875 (2010-10-26)
IL-9 is a pleiotropic cytokine that has multiple effects on structural as well as numerous hematopoietic cells, which are central to the pathogenesis of asthma. The contribution of IL-9 to asthma pathogenesis has thus far been unclear, due to conflicting
Elizabeth C Nowak et al.
Immunology, 131(2), 169-173 (2010-08-03)
The production of interleukin-9 (IL-9) by CD4 T cells has gathered renewed interest as the result of the observation that its expression is broader than originally thought. This includes the production of IL-9 by a recently characterized subset of CD4
J C Renauld et al.
Proceedings of the National Academy of Sciences of the United States of America, 89(12), 5690-5694 (1992-06-15)
Interleukin 9 (IL-9) is a T-cell-derived lymphokine that induces the proliferation of various lymphoid and hemopoietic cells. A cDNA clone encoding the murine IL-9 receptor was isolated by expression cloning in COS cells and screening with 125I-labeled IL-9. Transient expression
Ulla-Angela Temann et al.
The Journal of clinical investigation, 109(1), 29-39 (2002-01-10)
IL-9 is a pleiotropic cytokine with multiple functions on many cell types involved in the pathology of human asthma. The constitutive overexpression of IL-9 in the lungs of transgenic mice resulted in an asthma-like phenotype. To define the contribution of
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