I17002
Interleukin-2 human
IL-2, recombinant, expressed in HEK 293 cells, suitable for cell culture, endotoxin tested
Synonym(s):
Interleukin-2 human, Interleukin-2, T-cell growth factor
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About This Item
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recombinant
expressed in HEK 293 cells
assay
≥98% (SDS-PAGE)
form
lyophilized powder
potency
≤4 ng/mL ED50
mol wt
15 kDa (glycosylated)
technique(s)
cell culture | mammalian: suitable
suitability
endotoxin tested
storage temp.
−20°C
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General description
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes.[1] It is a monomeric glycoprotein and proinflammatory cytokine,[2] and contains four-a-helix bundles in its structure.[3] IL-2 gene is mapped to human chromosome 4q27.[4] Recombinant human IL-2 is expressed in human 293 cells as a glycoprotein with a calculated molecular mass of 15 kDa. This protein is manufactured in human cells using an all-human production system, with full chemically defined ingredients and with no serum. The human cells expression system allows human-like glycosylation and folding, and often supports better stability of the protein in culture.
Biochem/physiol Actions
Interleukin-2 (IL-2) is a lymphokine that promotes the long-term proliferation of activated T cells and acts as an essential mediator of the immune response. IL-2 signals through the IL-2 receptor, majorly via the IL-2Ra subunit.[3] IL-2 signaling via IL-2/anti-IL-2 immune complexes aids immune surveillance improvement during suppressed immunity. It also effectively controls infection.[5] IL-2 plays a role in the activation and proliferation of natural killer (NK) cells,[3] induces γ-inter-feron and B cell growth factor secretion and modulates the expression of the IL-2 receptor. It also elicits anti-tumor immunity.[4] An elevated expression level of IL-2 along with other interleukins is observed in colorectal cancer.[6]
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lymphokine promotes long term growth of activated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-interferon and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.
Sequence
APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
Physical form
Supplied as a lyophilized powder containing phosphate buffered saline.
Analysis Note
The biological activity of recombinant human IL-2 was tested in culture by measuring its ability to stimulate proliferation of the mouse CTLL-2 cells (mouse cytotoxic T cell line).
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 3
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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