synthetic phosphopeptide derived from the region of IRS-1 phosphorylated on tyrosine 941.
Biochem/physiol Actions
Insulin receptor substrate-1 (IRS-1) is among the four IRS proteins (IRS-1-IRS-4) that mediate signalling by insulin receptor (IR) and insulin-like growth factor (IGF) receptor. IRS-1 has a pleckstrin homology domain and a phosphotyrosine-binding domain. Phosphorylation of the Tyr1179 residue in the SH-1 negatively regulates insulin. IRS-1 has the abililty to translocate to the nucleus, the mechanism of which is not very clear. Estrogen receptors (ER) α and β have a strong affinity to IRS-1, an important interaction in breast cancers and medulloblastomas. The expression of IRS-1 in prostate cancer is associated with lower tumor cell invasiveness.
Physical form
Solution in phosphate buffered saline, pH 7.4, containing 1 mg/mL BSA (IgG and protease free) and 0.05% sodium azide.
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