I1036
PI3K (p110β/p85α), active, His tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
DKFZp779K1237, GRB1, MGC133043, PIK3C1, PIK3CB, PIK3R1, p110β, p85α
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About This Item
UNSPSC Code:
12352200
recombinant
expressed in baculovirus infected Sf9 cells
product line
PRECISIO® Kinase
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
13-19 nmol/min·mg
mol wt
p110β ~111 kDa
p110β/p85α ~85 kDa
relevant disease(s)
cancer (prostate tumor)
shipped in
dry ice
Storage temp.
−70°C
Gene Information
human ... PIK3CB(5291) , PIK3R1(5295)
Biochem/physiol Actions
The PI3K (phosphatidylinositol-4,5-bisphosphate 3 kinase) comprises of a 110kDa catalytic subunit and a 85kDa regulatory subunit.[1] The p110β catalytic subunit (PIK3Cβ, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit β) controls the formation and stability of αIIbβ3 integrin adhesion bonds. This event is needed for shear force-mediated platelet activation.[2] Absence of p110β impedes tumorigenesis in animals having prostate tumor, due to loss of PTEN (phosphatase and tensin homolog).[3]
Physical form
Supplied in 50 mM Sodium Phosphate, pH 7.0, with 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Shaun P Jackson et al.
Nature medicine, 11(5), 507-514 (2005-04-19)
Platelet activation at sites of vascular injury is essential for the arrest of bleeding; however, excessive platelet accumulation at regions of atherosclerotic plaque rupture can result in the development of arterial thrombi, precipitating diseases such as acute myocardial infarction and
Mattia Barbareschi et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 13(20), 6064-6069 (2007-10-20)
In breast cancer, the PIK3CA gene is frequently mutated at "hotspots" in exons 9 and 20, corresponding to the helical and kinase domains, respectively. We decided to investigate the association of PIK3CA mutations with pathologic features and clinical outcome in
Shidong Jia et al.
Nature, 454(7205), 776-779 (2008-07-03)
On activation by receptors, the ubiquitously expressed class IA isoforms (p110alpha and p110beta) of phosphatidylinositol-3-OH kinase (PI(3)K) generate lipid second messengers, which initiate multiple signal transduction cascades. Recent studies have demonstrated specific functions for p110alpha in growth factor and insulin
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