I0529

Anti-Interleukin-16 antibody produced in goat

affinity isolated antibody, lyophilized powder

• Synonym(s): Anti-IL-16
• MDL number: MFCD01635715
• UNSPSC Code: 51111800
• NACRES: NA.41

Properties

• biological source: goat
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: lyophilized powder
• species reactivity: human
• technique(s): indirect ELISA: 0.5-1.0 μg/mL; western blot: 0.1-0.2 μg/mL
• UniProt accession no.: Q14005
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... IL16(3603)

Description

General description

Interleukin-16 is also known as lymphocyte chemoattractant factor (LCF) and acts as chemoattractant for human T cells. IL-16 is secreted by cells of immune system such as T cells, dendritic cells and eosinophils. It is also secreted by the non-immune cells such as endothelial cells, fibroblasts and neurons. IL-16 is biologically active in the multimeric form and binds to CD4 and CCR5 receptors. The signaling induced by IL-16 activates pathways that involve MAPK, PI3K and SAPK. The biological activities of IL-16 are important for inflammation, migration, cell cycle progression, cell proliferation, development of Th1 cells and regulation of T cell responses. IL-16 signaling is important in the pathophysiology of Crohn′s disease, HIV infection, airway inflammation in asthma and rheumatoid arthritis. Anti-Interleukin-16 antibody recognizes human IL-16.

Immunogen

recombinant human IL-16 expressed in E. coli.

Application

Anti-Interleukin-16 antibody may be used for immunoblotting at a working antibody concentration of 0.1-0.2 μg/ml. For ELISA, a working concentration of 0.5-1.0 μg/ml is recommended.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable