I0281
Interleukin-4/Fc Chimera (non-lytic) from mouse
>98% (SDS-PAGE), recombinant, expressed in CHO cells, buffered aqueous solution
Synonym(s):
IL-4:Fc (non-lytic)
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About This Item
biological source
mouse
recombinant
expressed in CHO cells
assay
>98% (SDS-PAGE)
form
buffered aqueous solution
mol wt
98 kDa
packaging
pkg of 10 μg
impurities
endotoxin, tested
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Il4(16189)
Biochem/physiol Actions
In mice, absence of IL-4 (interleukin-4) causes anxiety-like behavior. It is secreted by Th2 (T helper) cells and works as a pro-inflammatory cytokine. It plays an important role in immune response and allergic diseases. It is also associated with schistosoma mansoni pulmonary hypertension.
Possesses the biological functions of the IL-4 moiety and a prolonged circulating half-life determined by the Fc domain.
Other Notes
Dimeric fusion protein consisting of mouse IL-4 fused to mutant mouse Fcγ2a Fc.
Physical form
Solution in 0.2 μm filtered phosphate buffered saline, pH 7.4.
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Morgan L Moon et al.
Behavior genetics, 45(4), 451-460 (2015-03-17)
Inflammation is a recognized antecedent and coincident factor when examining the biology of anxiety. Little is known, however, about how reductions in endogenous anti-inflammatory mediators impact anxiety. Therefore, mood- cognition- and anxiety-associated/like behaviors were examined in IL-4 knock out (KO)
Rahul Kumar et al.
American journal of respiratory and critical care medicine, 192(8), 998-1008 (2015-07-21)
The etiology of schistosomiasis-associated pulmonary arterial hypertension (PAH), a major cause of PAH worldwide, is poorly understood. Schistosoma mansoni exposure results in prototypical type-2 inflammation. Furthermore, transforming growth factor (TGF)-β signaling is required for experimental pulmonary hypertension (PH) caused by
K Oeser et al.
Mucosal immunology, 8(3), 672-682 (2014-10-23)
Approximately one-third of the world population is infected with gastrointestinal helminths. Studies in mouse models have demonstrated that the cytokines interleukin (IL)-4 and IL-13 are essential for worm expulsion, but the critical cellular source of these cytokines is poorly defined.
Kihyuk Shin et al.
Nature communications, 6, 6196-6196 (2015-02-05)
Lymphatic vessels (LVs) are critical for immune surveillance and involved in the pathogenesis of diverse diseases. LV density is increased during inflammation; however, little is known about how the resolution of LVs is controlled in different inflammatory conditions. Here we
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