HPA036380
Anti-ARHGAP31 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonym(s):
Anti-CDGAP, Anti-Rho GTPase activating protein 31
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100 μL
$598.00
About This Item
$598.00
Check Cart for Availability
Notify Me
Get notified when this item is ready to ship via email.
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
technique(s)
immunohistochemistry: 1:200- 1:500
immunogen sequence
QDLDIVAHALTGRRNSAPVSVSAVRTSFMVKMCQARAVPVIPPKIQYTQIPQPLPSQSSGENGVQPLERSQEGPSSTSGTTQKPAKDDSPSSLESSKEE
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ARHGAP31(57514)
General description
The gene ARHGAP31 (Rho GTPase activating protein 31) is mapped to human chromosome 3q13.3. It is ubiquitously expressed. The encoded protein has a GAP (GTPase-activating protein) domain, a basic-rich central region, a proline-rich domain and an extended C-terminal region.
Immunogen
Rho GTPase activating protein 31 recombinant protein epitope signature tag (PrEST)
Application
All Prestige Antibodies®Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-ARHGAP31 antibody produced in rabbit has ben used in western blotting and immunohistochemistry.[1]
Anti-ARHGAP31 antibody produced in rabbit has ben used in western blotting and immunohistochemistry.[1]
Biochem/physiol Actions
ARHGAP31 (Rho GTPase activating protein 31) is a Rac1 (Ras-related C3 botulinum toxin substrate 1) and Cdc42 (cell division control protein 42 homolog) specific GTPase activating protein. It works in integrin-dependent manner. ARHGAP31 is present on the focal adhesions (FAs) located on rigid surfaces and is responsible for cell migration, FA size and FA dynamics. Mutations in this gene result in Adams-Oliver disease, characterized with congenital scalp defects and terminal transverse limb defects.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Linkage
Corresponding Antigen APREST78412
Physical form
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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A stretch of polybasic residues mediates Cdc42 GTPase-activating protein (CdGAP) binding to phosphatidylinositol 3,4,5-trisphosphate and regulates its GAP activity.
Karimzadeh F, et al.
The Journal of Biological Chemistry, 287, 19610-19621 (2012)
The focal adhesion-localized CdGAP regulates matrix rigidity sensing and durotaxis.
Wormer DB, et al.
PLoS ONE, 9, e91815-e91815 (2014)
The emerging role of genomics in the diagnosis and workup of congenital urinary tract defects: a novel deletion syndrome on chromosome 3q13.31-22.1.
Materna-Kiryluk A, et al.
Pediatric Nephrology (Berlin), 29, 257-267 (2014)
Ali Ben Djoudi Ouadda et al.
Oncotarget, 9(14), 11646-11664 (2018-03-17)
Cdc42 GTPase-activating protein (CdGAP, also named ARHGAP31) is a negative regulator of the GTPases Rac1 and Cdc42. Associated with the rare developmental disorder Adams-Oliver Syndrome (AOS), CdGAP is critical for embryonic vascular development and VEGF-mediated angiogenesis. Moreover, CdGAP is an
Isolated terminal limb reduction defects: extending the clinical spectrum of Adams-Oliver syndrome and ARHGAP31 mutations.
Isrie M, et al.
American Journal of Medical Genetics, 164A, 1576-1579 (2014)
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