HPA020031
Anti-INHBA antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonym(s):
Anti-Activin beta-A chain, Anti-EDF, Anti-Erythroid differentiation protein, Anti-Inhibin beta A chain
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About This Item
UNSPSC Code:
12352203
Human Protein Atlas Number:
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
technique(s)
immunohistochemistry: 1:200- 1:500
immunogen sequence
KKHILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTIRLFQQQKHPQGSLDTGEE
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... INHBA(3624)
General description
INHBA (Inhibin, β A) is a morphogen belonging to the TGFβ superfamily. It encodes a protein reffered to as activin A. It is expressed in both α- and β-cells of pancreatic islets. It is composed of two nearly anti-parallel activin A monomers separated by a 2-fold symmetry axis. Each monomer consists of the canonical TGF-β fold.
Immunogen
Inhibin beta A chain Precursor recombinant protein epitope signature tag (PrEST)
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
Biochem/physiol Actions
INHBA (Inhibin, β A) is associated with various cellular activities such as cell differentiation, proliferation, activation and apoptosis. It has binding affinity for both the type I and type II serine/threonine kinase receptors. INHBA directly binds to the extracellular domain of the type II receptor, ActRIIB, which further adhere to the outer edges of the activin finger regions. It controls genetic expression of islet β cells. In non-small cell lung cancer (NSCLC), it acts as an autocrine factor in the maintenance of mesenchymal properties of cancer-initiating cells (CICs) to promote metastasis.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Linkage
Corresponding Antigen APREST84518.
Physical form
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Yiyang Dai et al.
Translational oncology, 11(1), 116-124 (2017-12-10)
Barrett's esophagus metaplasia is the key precursor lesion of esophageal adenocarcinoma. The aim of this study was to find a subset of markers that may allow the identification of patients at risk for esophageal adenocarcinoma, and to determine genes differentially
Michela Locci et al.
Nature immunology, 17(8), 976-984 (2016-07-05)
Follicular helper T cells (TFH cells) are CD4(+) T cells specialized in helping B cells and are associated both with protective antibody responses and autoimmune diseases. The promise of targeting TFH cells therapeutically has been limited by fragmentary understanding of
J Jacob Wamsley et al.
Cancer research, 75(2), 426-435 (2014-11-30)
Soluble growth factors and cytokines within the tumor microenvironment aid in the induction of the epithelial-to-mesenchymal transition (EMT). Although EMT promotes the development of cancer-initiating cells (CIC), cellular mechanisms by which cancer cells maintain mesenchymal phenotypes remain poorly understood. Work
Itaru Hashimoto et al.
Cancers, 14(18) (2022-09-24)
We sought to identify an optimal combination of survival risk stratification markers in patients with pathological (p) stage II/III gastric cancer (GC) after curative resection. We measured the expression levels of 127 genes in pStage II/III GC tissues of two
Thomas B Thompson et al.
The EMBO journal, 22(7), 1555-1566 (2003-03-28)
The TGF-beta superfamily of ligands and receptors stimulate cellular events in diverse processes ranging from cell fate specification in development to immune suppression. Activins define a major subgroup of TGF-beta ligands that regulate cellular differentiation, proliferation, activation and apoptosis. Activins
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