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HPA002730

Sigma-Aldrich

Anti-BAZ1A antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-ATP-dependent chromatin remodelling protein antibody produced in rabbit, Anti-ATP-utilizing chromatin assembly and remodeling factor 1 antibody produced in rabbit, Anti-Bromodomain adjacent to zinc finger domain protein 1A antibody produced in rabbit, Anti-Williams syndrome transcription factor-related chromatin-remodeling factor 180 antibody produced in rabbit, Anti-hACF1 antibody produced in rabbit

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100 μL
$598.00

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100 μL
$598.00

About This Item

UNSPSC Code:
12352203
Human Protein Atlas Number:
HPA002730
NACRES:
NA.41

$598.00

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

technique(s)

immunohistochemistry: 1:20-1:50

immunogen sequence

RGHRESALKETLLQEKSRICAQLARFSEEKFHFSDKPQPDSKPTYSRGRSSNAYDPSQMCAEKQLELRLRDFLLDIEDRIYQGTLGAIKVTDRHIWRSALESGRYELLSEENKENGIIKTVNEDVEEMEIDEQTK

UniProt accession no.

Q9NRL2

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BAZ1A(11177)

Related Categories

Immunogen

Bromodomain adjacent to zinc finger domain protein 1A recombinant protein epitope signature tag (PrEST)

Application

Anti-BAZ1A antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Biochem/physiol Actions

BAZ1A (bromodomain adjacent to zinc finger domain 1A) is involved in the ATP-dependent ′nucleosome remodelling′ activity. It is a subunit of Drosophila ACF (ATP-dependent chromatin assembly factor large subunit). In Drosophila, BAZ1A forms a heteromer chromatin remodelling complex with the nucleosome-dependent ATPase ISWI (imitation swi). This complex has the ability to bind naked DNA but not nucleosomal DNA. It catalyzes the process of transfering histone octamers between DNA segments. The BAZ1A-ISWI heteromer also interacts with small histone fold proteins CHRAC (chromatin accessibility complex)-14 and CHRAC-16 during nucleosome remodelling.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST70546

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
A91776
R00306
R000306

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A Eberharter et al.
The EMBO journal, 20(14), 3781-3788 (2001-07-12)
The chromatin accessibility complex (CHRAC) was originally defined biochemically as an ATP-dependent 'nucleosome remodelling' activity. Central to its activity is the ATPase ISWI, which catalyses the transfer of histone octamers between DNA segments in cis. In addition to ISWI, four
Ram Prakash Yadav et al.
Reproduction (Cambridge, England), 165(1), 49-63 (2022-10-05)
Proper regulation of heterochromatin is critical for spermatogenesis. This study reveals the dynamic localization patterns of distinct chromatin regulators during spermatogenesis and disrupted sex chromatin status in spermatocytes in the absence of DICER. Heterochromatin is dynamically formed and organized in
R A Poot et al.
The EMBO journal, 19(13), 3377-3387 (2000-07-06)
Chromatin remodelling complexes containing the nucleosome-dependent ATPase ISWI were first isolated from Drosophila embryos (NURF, CHRAC and ACF). ISWI was the only common component reported in these complexes. Our purification of human CHRAC (HuCHRAC) shows that ISWI chromatin remodelling complexes
James A Dowdle et al.
PLoS genetics, 9(11), e1003945-e1003945 (2013-11-19)
ATP-dependent chromatin remodelers control DNA access for transcription, recombination, and other processes. Acf1 (also known as BAZ1A in mammals) is a defining subunit of the conserved ISWI-family chromatin remodelers ACF and CHRAC, first purified over 15 years ago from Drosophila

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