HPA002704
Anti-MAPK15 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonym(s):
Anti-Extracellular signal-regulated kinase 8 antibody produced in rabbit, Anti-Mitogen-activated protein kinase 15 antibody produced in rabbit
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About This Item
UNSPSC Code:
12352203
Human Protein Atlas Number:
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunogen sequence
KTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDF
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... MAPK15(225689)
General description
MAPK15 (mitogen-activated protein kinase 15) is an atypical member of MAPK family with a conserved PCNA-interacting protein (PIP) box and the PXXXP (proline rich) motif in carboxyl terminal end. It exhibits high kinase activity. It is localized at the Golgi complex. It possesses an atypically long C-terminal domain for auto-phosphorylation of its Thr-X-Tyr motif.[1]
Immunogen
Mitogen-activated protein kinase 15 recombinant protein epitope signature tag (PrEST)
Application
Anti-MAPK15 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem/physiol Actions
MAPK15 (mitogen-activated protein kinase 15) is involved in the proliferating cell nuclear antigen (PCNA) protein stability. It is a major regulator of PCNA complex formation in mammary epithelial cells. In association with homologue of murine double minute (HDM2), it prevents the loss of PCNA during DNA damage and mitotic failure.[1] It plays a role in the DNA repair of single strand breaks through a proteasome-dependent mechanism. In the Golgi complex it inhibits COP-I vesicle formation, which is essential for the formation of transport carriers. It also restrict the export of GalNAc-Ts (GaINAc (N-acetylgalactosamine)-transferases).
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Linkage
Corresponding Antigen APREST85135.
Physical form
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Joanne Chia et al.
eLife, 3, e01828-e01828 (2014-03-13)
ER O-glycosylation can be induced through relocalisation GalNAc-Transferases from the Golgi. This process markedly stimulates cell migration and is constitutively activated in more than 60% of breast carcinomas. How this activation is achieved remains unclear. Here, we screened 948 signalling
Iva V Klevernic et al.
FEBS letters, 583(4), 680-684 (2009-01-27)
We have investigated the agonists that activate transfected extracellular signal-regulated kinase 8 (ERK8) in cells, and have found that the most potent activators are hydrogen peroxide, DNA alkylating and cross-linking agents and the poly (ADP-ribose) polymerase inhibitor KU-0058948. The feature
Angela L Groehler et al.
The Journal of cell biology, 190(4), 575-586 (2010-08-25)
Proliferating cell nuclear antigen (PCNA) acts as a scaffold, coordinator, and stimulator of numerous processes required for faithful transmission of genetic information. Maintaining PCNA levels above a critical threshold is essential, but little is known about PCNA protein turnover. We
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