H9915

Anti-HOXB6 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-HOX-2B, Anti-HOX2.2, Anti-HU-2
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~30 kDa
• species reactivity: human
• concentration: ~1.0 mg/mL
• technique(s): western blot: 0.5-1 μg/mL using using lysates of HEK-293T cells over expressing human HOXB6
• UniProt accession no.: P17509
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... HOXB6(3216) ; mouse ... Hoxb6(15414)

Description

General description

Homeobox 6 (HOXB6) protein is expressed in human hematopoietic progenitor cells (HPCs). The HOXB6 gene is mapped on the human chromosome at 17q21.32.

Specificity

Anti-HOXB6 (C-terminal) recognizes human HOXB6 (also known as HOX2B, HU-2 and Hox-2.

Immunogen

synthetic peptide corresponding to amino acids 108-122 of human HOXB6 conjugated to KLH. The corresponding sequence is identical in mouse.

Application

Anti-HOXB6 (C-terminal) antibody produced in rabbit may be used in immunoblotting.

Biochem/physiol Actions

Homeobox 6 (HOXB6) is frequently overexpressed in human acute myeloid leukemia (AML). HOXB6 gene overexpression extended hematopoietic stem cells (HSCs) and myeloid precursors while decreasing erythropoiesis and lymphopoiesis.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Storage and Stability

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)