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H9790

Sigma-Aldrich

Anti-HOXA5 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-HOX1, Anti-HOX1.3, Anti-HOX1C, Anti-Homeo box 1C, Anti-Homeo box A5

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About This Item

MDL number:
MFCD02263083
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~40 kDa

species reactivity

human

concentration

~1.0 mg/mL

technique(s)

western blot: 0.5-1 μg/mL using using lysates of HEK-293T cells over-expressing human HOXA5

UniProt accession no.

P20719

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HOXA5(3202)
mouse ... Hoxa5(15402)
rat ... Hoxa5(79241)

General description

Homeobox A5 (HOXA5) is mapped to human chromosome 7p15.2. It belongs to amino acid Antennapedia (Antp) -class homeodomain proteins.

Application

Anti-HOXA5 antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Homeobox A5 (HOXA5) mediates organogenesis and development of mammary glands, lungs, digestive tract and thyroid. It is essential for ovary homeostasis. Mutation in HOXA5 gene hampers organogenesis as it affects axial specification in the cervico-thoracic level. HOXA5 has been shown to play an important role in breast tumorigenesis. It also regulates hematopoiesis by interacting with pleiotrophin (PTN).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
029K4765

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Hoxa5: a key player in development and disease
Jeannotte L, et al.
Journal of developmental biology, 4(2), 13-13 (2016)
Compromised HOXA5 function can limit p53 expression in human breast tumours
Raman V, et al.
Nature, 405(6789), 974-974 (2000)
HOXA5-Mediated Stabilization of II?BI? Inhibits the NF-I?B Pathway and Suppresses Malignant Transformation of Breast Epithelial Cells.
Pai, et al.
Cancer research, 82, 3802-3814 (2023)
Identification of transcriptional targets of HOXA5
Chen H, et al.
The Journal of Biological Chemistry, 280(19), 19373-19380 (2005)
Effect of silencing HOXA5 gene expression using RNA interference on cell cycle and apoptosis in Jurkat cells
Huang HP, et al.
International Journal of Molecular Medicine, 37(3), 669-678 (2016)

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