H9776
Heat Shock Protein 70 from bovine brain
>95% (SDS-PAGE), lyophilized powder
Synonym(s):
HSP 70
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About This Item
UNSPSC Code:
12352202
Recommended Products
biological source
bovine brain
assay
>95% (SDS-PAGE)
form
lyophilized powder
composition
Protein, ~10% Lowry
technique(s)
western blot: suitable
storage temp.
−20°C
Gene Information
bovine ... HSPA1A(282254) , HSPA8(281831)
Application
Heat shock protein 70 (Hsp70) from bovine brain has been used as a protein standard in Western blotting to check levels of the Hsp70 family proteins in honey bees after heat exposure.[1] It has been used as a standard for the quantification of HSP70, obtained from liver sections of rats, by ELISA (enzme-linked immunosorbent assay).[2]
Biochem/physiol Actions
HSPs (heat shock proteins) are needed for protein folding, protein assembly, protein aggregation and protein transport. They help in maintaining cellular homeostasis and offer cytoprotective effects.[3] Hsp70 is associated with the protective effects on rat myocardial cells in presence of heat stress.[4] Similarly, it offers neuro-protection from oxygen-glucose deprivation injury.[5]
Physical form
Contains Tris buffer salts.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Hongbo Chen et al.
Molecular medicine reports, 11(3), 2276-2284 (2014-11-21)
The aim of the present study was to investigate the association between heat shock protein (Hsp) 70 expression kinetics and heat stress‑induced damage to rat myocardial cells in vitro and in vivo. The results showed that the activity of heart
Jian-hua Zhao et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 34(1), 18-22 (2014-02-06)
In the present study, we examined the effect of oxygen glucose deprivation (OGD) post-conditioning (PostC) on neural cell apoptosis in OGD-PostC model and the protective effect on primary cortical neurons against OGD injury in vitro. Four-h OGD was induced by
Michelle M Elekonich
Cell stress & chaperones, 14(2), 219-226 (2008-08-13)
Foraging honey bees frequently leave the hive to gather pollen and nectar for the colony. This period of their lives is marked by periodic extremes of body temperature, metabolic expenditure, and flight muscle activity. Following ecologically relevant episodes of hyperthermia
Takehiro Sakai et al.
Transplant international : official journal of the European Society for Organ Transplantation, 16(2), 88-99 (2003-02-22)
We focused on heat shock protein 70 (HSP70) as a marker of viability in hepatic warm ischemia-reperfusion. Segmental hepatic warm ischemia was produced in rats for 15, 30, 60, 90, 120, or 180 min. Liver sections were evaluated at 30
Haining Li et al.
Life sciences, 234, 116747-116747 (2019-08-14)
The present study was aimed to investigate the neuroprotective effect of HSP70 against neuroinflammation in a rotenone-induced Parkinson's disease model. In the present study, SH-SY5Y cells were treated with HSP70 (5-20 mg/L) for 72 h. Cell viability, reactive oxygen species (ROS) levels
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