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H3290

Sigma-Aldrich

HIPK1 (156-555), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

KIAA0630, MGC26642, MGC33446, MGC33548, Myak, Nbak2

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About This Item

UNSPSC Code:
51111800
NACRES:
NA.32

recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

200

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

~71 kDa

UniProt accession no.

Q86Z02

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... HIPK1(204851)

General description

HIPK1 (homeodomain-interacting protein kinase 1) is a serine/threonine protein kinase. It belongs to the HIPK family. The protein is present in the nucleus.[1]

Biochem/physiol Actions

HIPK1 (homeodomain-interacting protein kinase 1) is responsible for phosphorylation of homeodomain transcription factors. HIPK1 interacts with DAXX (death domain-associated protein 6) and decreases its transcriptional repression activity.[1] It is up-regulated in breast cancer cell lines and is suggested to be involved in tumorigenesis, partly by serine phosphorylation of p53.[2]

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Seiji Kondo et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(9), 5431-5436 (2003-04-19)
The tumor suppressor p53 is regulated in part by binding to cellular proteins. We used p53 as bait in the yeast two-hybrid system and isolated homeodomain-interacting protein kinase 1 (HIPK1) as a p53-binding protein. Deletion analysis showed that amino acids
Jeffrey A Ecsedy et al.
Molecular and cellular biology, 23(3), 950-960 (2003-01-17)
We describe an interaction between homeodomain-interacting protein kinase 1 (HIPK1) and Daxx, two transcriptional regulators important in transducing growth-regulatory signals. We demonstrate that HIPK1 is ubiquitously expressed in mice and humans and localizes predominantly to the nucleus. Daxx normally resides

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