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H2036

Rp-8-Hexylaminoadenosine 3′,5′-monophosphorothioate

Name: Rp-8-Hexylaminoadenosine 3′,5′-monophosphorothioate
Brand: SIGMA

solid, ≥99% (HPLC)

Synonym(s):

Rp-8-HA-cAMPS

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₂₄N₆O₅PSNa

Molecular Weight:

466.43

UNSPSC Code:

41106305

PubChem Substance ID:

329815181

NACRES:

NA.77

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Product Name

Rp-8-Hexylaminoadenosine 3′,5′-monophosphorothioate, ≥99% (HPLC), solid

biological source

synthetic (organic)

Quality Level

200

assay

≥99% (HPLC)

form

solid

packaging

vial of 5 μmol (approx. 2 mg)

storage temp.

−20°C

SMILES string

NC1=NC=NC2=C1N=C(NCCCCCC)N2[C@H]3[C@H](O)[C@@H](O[P@]4(O)=S)C(CO4)O3

InChI

1S/C16H25N6O5PS/c1-2-3-4-5-6-18-16-21-10-13(17)19-8-20-14(10)22(16)15-11(23)12-9(26-15)7-25-28(24,29)27-12/h8-9,11-12,15,23H,2-7H2,1H3,(H,18,21)(H,24,29)(H2,17,19,20)/t9-,11-,12-,15-,28?/m1/s1

InChI key

IYCUPZSIJJABKU-IYKFWPKASA-N

Biochem/physiol Actions

Membrane permeable metabolically stable inhibitor of cAMP-dependent protein kinases

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Effects of gap junctional blockers on cerebral vasospasm after subarachnoid hemorrhage in rabbits.

Tao Hong et al.

Neurological research, 31(3), 238-244 (2008-08-02)

The role of gap junctional communication in the coordination of vascular behavior has been well established experimentally. The aim of this study was to investigate whether the gap junctional blockers would inhibit cerebral vasospasm after experimental subarachnoid hemorrhage (SAH). We

Novel (Rp)-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1 beta action.

B T Gjertsen et al.

The Journal of biological chemistry, 270(35), 20599-20607 (1995-09-01)

Novel (Rp)-cAMPS analogs differed widely in ability to antagonize cAMP activation of pure cAMP-dependent protein kinase I and II and to antagonize actions of cAMP on gene expression, shape change, apoptosis, DNA replication, and protein phosphorylation in intact cells. These

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