H1416
Anti-HOXB13 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Homeobox B13
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~30 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 2.5-5 μg using lysates of HeLa cells
western blot: 2-4 μg/mL using extracts of HEK-293T cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HOXB13(10481)
General description
The HOXB13 gene is located on the human chromosome at 17q21.32. This gene is expressed in both fetal dermis and proliferating fibroblasts.
Specificity
Anti-HOXB13 recognizes human HOXB13.
Immunogen
synthetic peptide corresponding to amino acids 270-284 of human HOXB13, conjugated to KLH. The corresponding sequence differs by 2 amino acids in mouse and rat.
Application
Anti-HOXB13 antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.
Biochem/physiol Actions
Homeobox B13 (HOXB13) gene expression is essential for amphibian limb regeneration. It plays a role in fetal skin development and cutaneous regeneration as a result of wounding. HOXB13 gene is overexpressed in human endometrial, breast, ovarian and cervical carcinomas and is associated with the invasiveness of ovarian and endometrial cancer cells. Mutations in the HOXB13 gene leads to prostate cancer.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Hannah Brechka et al.
Genes & diseases, 4(2), 75-87 (2017-08-12)
The recent and exciting discovery of germline HOXB13 mutations in familial prostate cancer has brought HOX signaling to the forefront of prostate cancer research. An enhanced understanding of HOX signaling, and the co-factors regulating HOX protein specificity and transcriptional regulation
R López et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 16(1), 329-335 (2006-02-01)
The homeobox (HOX) genes are a family of transcription factors that bind to specific DNA sequences in target genes regulating gene expression. Thirty-nine HOX genes have been mapped in four conserved clusters: A, B, C, and D; they act as
E J Stelnicki et al.
The Journal of investigative dermatology, 111(1), 57-63 (1998-07-17)
Scarless healing of cutaneous wounds occurs in humans during the first two trimesters of development, but by birth all wounds are repaired with scar formation. To search for transcriptional regulatory genes that might mediate fetal tissue regeneration, we surveyed homeobox
Yawei Zhao et al.
Oncology reports, 13(4), 721-726 (2005-03-10)
During the last two decades, a group of homeobox-containing genes, the HOX gene family, has been studied both in the context of embryonic development and neoplasia. In particular, there is accumulating evidence of the involvement of HOX abnormalities in a
Tsuyoshi Yamashita et al.
International journal of oncology, 28(4), 931-938 (2006-03-10)
HOX genes encode transcription factors that function to establish basic body pattern during embryogenesis and maintain the function of specific organs in the adult. Recent studies have demonstrated that HOX genes are also involved in oncogenesis in a range of
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