The HOXA1 gene is a member of the homeobox (HOX) gene family and is mapped on the human chromosome at 7p15.2.
Specificity
Anti-HOXA1 specifically recognizes human HOXA1 (also known as Hox-1F, HXA1).
Application
Anti-HOXA1 antibody produced in rabbit may be used in immunoblotting.
Biochem/physiol Actions
Homeobox A1 (HOXA1) protein is involved in hindbrain segmentation and patterning. Misregulation of the HOXA1 gene is associated with breast cancer. HOXA1 gene disruption results in abnormal ossification of the skull, hindbrain, and inner ear deficiencies, and neonatal death.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Hox proteins are transcription factors involved in crucial processes during animal development. Their mode of action remains scantily documented. While other families of transcription factors, like Smad or Stat, are known cell signaling transducers, such a function has never been
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