H1041
Anti-HOXC10 (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Homeobox C10, Anti-Homeoprotein C10
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~45 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 5-10 μg using lysate of HEK-293T cells over-expressing human HOXC10
western blot: 1-2 μg/mL using lysates of HEK-293T cells over-expressing human HOXC10
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HOXC10(3226)
General description
Homeobox C10 (HOXC10) protein expression is cell-type-dependent. The HOXC10 gene is a member of the HOX gene family. This gene encodes for a protein that consists of conserved DNA binding homeodomain. The HOXC10 gene is mapped on the human chromosome at 12q13.13.
Specificity
Anti-HOXC10 (C-terminal) recognizes human HOXC10.
Application
Anti-HOXC10 (C-terminal) antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.
Biochem/physiol Actions
Homeobox C10 (HOXC10) is associated with cell proliferation. HOXC10 is targeted for degradation, early in mitosis by the ubiquitin-proteasome pathway. HOXC10 gene is expressed at higher levels in thyroid cancer, cervical cancer, and lung adenocarcinoma. Upregulation of HOXC10 gene expression is associated with proliferation, invasion, and migration of gliomas. Overexpression of the HOXC10 gene is observed in breast carcinoma.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Bingzong Li et al.
Stem cells (Dayton, Ohio), 37(2), 247-256 (2018-10-26)
The characteristics of mesenchymal stromal cells (MSCs) which derived from multiple myeloma (MM) patients are typically impaired in osteogenic differentiation. However, the underlying molecular mechanisms need to be further investigated. lncRNAs are emerging as critical regulation molecules in oncogenic pathways.
Helen Sadik et al.
Cancer research, 76(15), 4443-4456 (2016-06-16)
Development of drug resistance is a major factor limiting the continued success of cancer chemotherapy. To overcome drug resistance, understanding the underlying mechanism(s) is essential. We found that HOXC10 is overexpressed in primary carcinomas of the breast, and even more
E de Stanchina et al.
Journal of molecular biology, 299(3), 667-680 (2000-06-03)
We have previously shown that a cell cycle-dependent nucleoprotein complex assembles in vivo on a 74 bp sequence within the human DNA replication origin associated to the Lamin B2 gene. Here, we report the identification, using a one-hybrid screen in
Zhanyao Tan et al.
Theranostics, 8(18), 5143-5158 (2018-11-16)
High levels of angiogenesis are associated with poor prognosis in patients with gliomas. However, the molecular mechanisms underlying tumor angiogenesis remain unclear. Methods: The effect of homeobox C10 (HOXC10) on tube formation, migration, and proliferation of human umbilical vein endothelial
Davide Gabellini et al.
The EMBO journal, 22(14), 3715-3724 (2003-07-11)
Hox proteins are transcription factors involved in controlling axial patterning, leukaemias and hereditary malformations. Here, we show that HOXC10 oscillates in abundance during the cell cycle, being targeted for degradation early in mitosis by the ubiquitin-dependent proteasome pathway. Among abdominal-B
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